1．有机磷化合物的绿色合成与应用

2．生物质（羧酸及其衍生物）的转化

3．药物与材料的设计开发

2004.06-2013.12，湖南大学,本硕博，硕士生导师：郭灿城教授，博士生导师：郭灿城教授，韩立彪教授 （为卟啉化合物和金属卟啉化合物的实验室公斤级合成、中试千吨级合成，烯基膦化合物的产业化合成做出了贡献）。

2010.04-2013.03，日本产业技术综合研究所，联合培养

2014.01-2017.10，湖南大学，助理研究员，副教授

2016.01-2017.03，日本产业技术综合研究所，特别研究员（博士后）

2017.10-2019.01，海南大学，高聘教授

2018.12-至今，海南大学，教授

[1]Chen T Q,Zhao C-Q, Han L-B.* Hydrophosphorylation of Alkynes Catalyzed by Palladium: Generality and Mechanism. Journal of the American Chemical Society, 2018, 140, 3139–3155 (JCR一区, IF: 13.858).

[2] Zhu Y Y,Chen T Q,*Li S, Shimada S, Han L-B.* Efficient Pd-Catalyzed Dehydrogenative Coupling of P(O)H with RSH: a Precise Construction of P(O)-S Bonds. Journal of the American Chemical Society, 2016, 138, 5825–5828 (Organic Chemistry Portal highlights, JCR一区, IF: 13.858).

[3] Yang J,Chen T Q,*Han L-B.* C-P Bond-Forming Reactions via C-O/P-H Cross Coupling Catalyzed by Nickel. Journal of the American Chemical Society, 2015, 137: 1782-1785(JCR一区, IF: 13.858).

[4]Chen T Q,*Han L-B.* Nickel-Catalyzed C-O/C-H Cross-Coupling Reactions for C-C Bond Formation. Angewandte Chemie International Edition, 2015, 54: 8600-8602 (JCR一区, Wiley-VCH Hot Topics: C-H activation, C-C coupling, IF: 11.994).

[5] Shen R W,†Chen T Q,†Zhao Y L, Qiu R H, Zhou Y B, Yin S F,* Wang X B, Goto M, Han L-B.* Facile Regio- and Stereoselective Hydrometalation of Alkynes with a Combination of Carboxylic Acids and Group 10 Transition Metal Complexes: Selective Hydrogenation of Alkynes with Formic Acid. Journal of the American Chemical Society, 2011, 133: 17037-17044 (†:并列第一作者, 第一单位第一作者)( Synfacts, ChemInform and ACIE highlight) (JCR一区, IF: 13.858).

[6] Zhang M-Z,* Liu L, Gou Q, Wang Q, Li Y, Li W-T, Luo F, Yuan M,Chen T Q,*He W-M.* Synthesis of Hydroxyl-Containing Oxindoles and 3,4-Dihydroquinolin-2-ones through Oxone-Mediated Cascade Arylhydroxylation of Activated Alkenes. Green Chemistry, 2020, DOI: 10.1039/D0GC02205E (JCR一区, IF: 9.5).

[7] Zhang J-S, Liu L.,Chen T Q,*Han L-B. Cross-Dehydrogenative Alkynylation: A Powerful Tool for the Synthesis of Internal Alkynes. ChemSusChem 2020, DOI: 10.1002/cssc.202001165.

[8] Xi X X,Chen T Q,*Zhang J-S, Han L-B. Efficient and Selective Hydrogenation of C-O Bonds with a Simple Sodium Formate Catalyzed by Nickel. Chemical Communications, 2018, 54, 1521-1524 (JCR一区, IF: 6.567).

[9] Xiao J, Yang J,Chen T Q,*Han L-B.* Nickel-Catalyzed Synthesis of (E)-Olefins from Benzylic Alcohol Derivatives and Arylacetonitriles via C-O Activation. Chemical Communications, 2016, 52, 2157-2160 (JCR一区, IF: 6.567).

[10] Yang J, Xiao J,Chen T Q,*Yin S-F,* Han L-B.* Efficient Nickel-catalyzed Phosphinylation of C-S Bonds Forming C-P Bonds. Chemical Communications, 2016, 52, 12233-12236 (JCR一区, IF: 6.567).

[11] Zhang J-S,Chen T Q,*Yang J, Han L-B.* Nickel-Catalysed P-C Bond Formation via P-H/C-CN Cross Couplings. Chemical Communications, 2015, 51, 7540-7542 (JCR一区, IF: 6.567).

[12] Yang J,Chen T Q,*Zhou Y B, Yin S F, Han L-B.* Palladium-Catalyzed Dehydrogenative Coupling of Terminal Alkynes with Secondary Phosphine Oxides. Chemical Communications, 2015, 51, 3549-3551 (JCR一区, IF: 6.567).

[13]Chen T Q,Guo C C,* Goto M, Han L -B.* A Brønsted acid-catalyzed generation of palladium complexes: efficient head-to-tail dimerization of alkynes. Chemical Communications, 2013, 49: 7498-7500 (ChemInform highlight) (JCR一区, IF: 6.567).

[14] Yu W Q, Liu L, Huang T Z, Zhou X B,Chen T Q,*Palladium-Catalyzed Decarbonylative Heck Coupling of Aromatic Carboxylic Acids with Terminal Alkenes. Oragnic Letters, 2020, DOI: 10.1021/acs.orglett.0c02462.

[15] Li Z, Liu L, Xu K, Huang T, Li X, Song B,Chen T Q.*Palladium-Catalyzed N-Acylation of Tertiary Amines by Car-boxylic Acids: A Method for the Synthesis of Amides. Organic Letters, 2020, DOI: 10.1021/acs.orglett.0c01869.

[16] Zhang J-S,Chen T Q,*Zhou Y, Yin S-F, Han L-B.* Catalytic sp3C-CN Bond Cleavage: Ni-Mediated Phosphorylation of Alkylnitriles. Organic Letters, 2018, DOI: 10.1021/acs.orglett.8b02854.

[17] Liu L, Zhu D, Liu M, Zhou Y,Chen T Q,*Palladium-Catalyzed Decarbonylative Alkynylation of Amides. Organic Letters, 2018, DOI: 10.1021/acs.orglett.8b00949 (JCR一区, IF: 6.732).

[18] Zhang J Q,Chen T Q,*Zhang J.-S., Han L.-B.* Silver-Free Direct Synthesis of Alkynylphosphine Oxides via spC-H/P(O)-H Dehydrogenative Coupling Catalyzed by Palladium. Organic Letters, 2017, 19, 4692-4695. (JCR一区, IF: 6.732).

[19] Xiao J,Chen T Q,*Han L-B.* Nickel-Catalyzed Direct C-H/C-O Cross Couplings Generating Fluorobenzenes and Heteroarenes. Organic Letters, 2015, 17: 812–815 (JCR一区, IF: 6.732).

[20] Zhao Y L,Chen T Q,*Han D Q, Zhao C-Q,* Han L-B.* Facile Base-Mediated Redox Transformation: An Efficient Strategy for the Synthesis of α Acyloxyphosphoryl Compounds. Organic Letters, 2014, 16: 6152-6155 (JCR一区, IF: 6.732).

[21] Xiao J, Yang J,Chen T Q,*Han L-B.* Nickel-Catalyzed α-Benzylation of Arylacetonitriles via C-O Activation. Advanced Synthesis & Catalysis, 2016, 358, 816-819 (JCR一区, IF: 6.453).

[22] Chen H,† Liu L,† Huang T, Chen J,*Chen T Q.*Direct Dehydrogenation for the Synthesis ofa,b-Unsaturated Carbonyl Compounds. Advanced Synthesis & Catalysis, 2020 DOI: 10.1002/adsc.202000454.

[23] Kang Xiang, Shuo Zhang, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li, Kaiqiang Xu andTieqiao Chen.*Tunable C-H Arylation and Acylation of Azoles with Carboxylic Acids by Pd/Cu Cooperative Catalysis. Organic Chemistry Frontiers, 2021, DOI: 10.1039/D1QO00380A.

[24] Ming-Zhong Zhang,* Jing Tian, Min Yuan, Wan-Qi Peng, Yu-Zhu Wang, Peng Wang, Long Liu, Quan Gou, Huisheng Huang andTieqiao Chen.*Visible Light-Induced Aerobic Dioxygenation of α,β-unsaturated amides/Alkenes toward Selective Synthesis of β-Oxy Alcohols Using Rose Bengal as a Photosensitizer. Organic Chemistry Frontiers, 2021, DOI:10.1039/D1QO00149C.

[25] Liu M,Chen T Q,*Yin S F.* Copper-Catalysed Aerobic Oxidative Esterification of N-Heteroaryl Methanes with Alcohols. Catalysis Science & Technology, 2016, 6, 690-693 (JCR一区, IF: 5.287).

[26] Liu M,Chen T Q,*Zhou Y B, Yin S F.* Transition Metal-Free Oxidative ortho-Acylation of Phenols with N-Heteroarylmethanes via Double C-H Activation. Catalysis Science & Technology, 2016, 6, 5792-5796 (JCR一区, IF: 5.287).

[27] Chen X L,†Chen T Q,†Ji F Y, Zhou Y B,* Yin S-F.* Iron-Catalyzed Aerobic Oxidative Functionalization of sp3C-H Bonds: a Versatile Strategy for the Construction of N-Heterocycles, Catalysis Science & Technology, 2015,5, 2197-2202 (†:并列第一作者) (JCR一区, IF: 6.453).

[28] Chen X L,†Chen T Q,†Li Q, Zhou Y B, Han L-B, Yin S-F.* Copper-Catalyzed Aerobic Oxidative Inert C-C and C-N Bond Cleavage: A New Strategy for the Synthesis of Tertiary Amides. Chemistry - A European Journal, 2014, 20: 12234-12238 (†:并列第一作者) (JCR一区,IF: 5.771).

[29] Long Liu, Yuanyuan Tang, Kunyu Wang, Tianzeng Huang,Tieqiao Chen.*Transition-Metal-Free and Base-Promoted Carbon-Heteroatom Bonds Formation via C-N Cleavage of Benzyl Ammonium Salts. The Journal of Organic Chemistry, 2021, DOI: 10.1021/acs.joc.0c02992.

[30] Xu K Q, Liu L, Li Z H, Huang T Z, Xiang K,Chen T Q.*Controllable Phosphorylation of Thioesters: Selective Synthesis of Aryl and Benzyl phosphoryl compounds. The Journal of Organic Chemistry, 2020, DOI: 10.1021/acs.joc.0c01557 (JCR一区, IF: 4.849).

[31] Huang T,Chen T Q,*Han L-B.* Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes. The Journal of Organic Chemistry, 2018, DOI:10.1021/acs.joc.7b03148 (JCR一区, IF: 4.849).

[32] Zhang M-Z,* Luo N, Long, R-Y, Gou X-T, Shi W-B, He S-H, Jiang Y, Chen J-Y,Chen, T Q.*Transition-Metal-Free Oxidative Aminooxyarylation of Alkenes: Annulations toward Aminooxylated Oxindoles. The Journal of Organic Chemistry, 2018, 83, 2369-2375 (JCR一区, IF: 4.849).

[33] Yang J,† Xiao J,†Chen T Q,*Han L-B.* Nickel-Catalyzed Phosphorylation of Phenol Derivatives via C-O/P-H Cross Coupling. The Journal of Organic Chemistry, 2016, 81: 3911-3916 (Organic Chemistry Portal highlights，JCR一区, IF: 4.894).

[34] Yang J,Chen T Q,*Zhou Y B, Yin S F, Han L-B.* Mechanistic Studies on the Palladium Catalyzed Cross Dehydrogenative Coupling of P(O)-H Compounds with Terminal Alkynes: Stereochemistry and Reactive Intermediates. Organometallics, 2015, 34: 5095-5098 (JCR一区，strongly support the acceptance, very impressive and well suited for publication, IF: 4.186).

[35] Zhang L, Liu L, Huang T, Dong Q,*Chen T Q.*Palladium-Catalyzed Cyclobutanation of Aryl Sulfonates through both C–O and C–H Cleavage. Organometallics, 2020, 39, 11, 2189-2196, DOI: 10.1021/acs.organomet.0c00338.

[36] Li C Y,Chen T Q,*Han L-B.* Iron-Catalyzed Clean Dehydrogenative Coupling of Alcohols with P(O)-H Compounds: a New Protocol for ROH Phosphorylation. Dalton Transactions, 2016,45, 14893-14897 (JCR一区, IF: 4.177).

[37]Chen T Q, Zhang J-S, Han L-B.* Dehydrogenative Coupling Involving P(O)-H Bonds: a Powerful Way for the Preparation of Phosphoryl Compounds. Dalton Transactions, 2016, 45, 1843-1849 (JCR一区, 2016年3月-2017年6月高被引论文, IF: 4.177).

[38] Li X,Chen T Q,*Saga Y, Han L-B.* Iron-Catalyzed Cross Coupling of P-H/C-O Bonds: Efficient Synthesis of α-Alkoxyphosphorus Compounds. Dalton Transactions, 2016, 45, 1877-1880 (JCR一区, IF: 4.177).

[39] Zhang J-S, Liu L,Chen T Q,*Han L-B, Transition Metal-Catalyzed Three-Component Difunctionalization of Alkenes, Chemistry – an Asian Journal, 2018, 13, 2277-2291 (Invited paper, JCR一区, IF: 4.083).

[40] Zhang J-S,Chen T Q,*Han L-B.* Palladium-Catalyzed Direct Decarbonylative Phosphorylation of Benzoic Acids with P(O)-H Compounds. European Journal of Organic Chemistry, 2020, 2020, 1148-1153.

[41] Huang Y,Chen T Q,*Li Q, Zhou Y B, Yin S F.* Copper Catalysed Direct Amidation of Methyl Groups with N-H Bonds. Organic & Biomolecular Chemistry, 2015, 13: 7289-7293 (JCR一区, IF: 3.559).

[42] Liu M, Chen X,Chen T Q,*Yin S F.* Facile and General Acid-Catalyzed Deuteration at Methyl Groups of N-Heteroarylmethanes. Organic & Biomolecular Chemistry, 2017, 15, 2507-2511 (JCR一区, IF: 3.559).

[43] Zhang J-S, Zhang J-Q,Chen T Q,*Han L-B.* t-BuOK-Mediated Reductive Addition of P(O)-H Compounds to Terminal Alkynes Forming β-Arylphosphine oxides. Organic & Biomolecular Chemistry, 2017, 15, 5462-5467 (JCR一区, IF: 3.559).

[44] Liu M, Chen X,Chen T Q,*Xu Q, Yin S F.* Metal-Free Oxidative para-Acylation of Unprotected Anilines with N-Heteroarylmethanes. Organic & Biomolecular Chemistry, 2017, 15, 9845-9854 (JCR一区, IF: 3.559).

[45] Chen L, Zhu Y Y,Chen T Q,*Liu L, Zhang J-S, Han L-B.* Direct C-OH/P(O)-H Dehydration Coupling Forming Phosphine Oxides. Organic & Biomolecular Chemistry, 2018, 16, 5090-5093.

[46] Zhang M-Z,* Wang X, Gong M-Y, Chen L, Shi W-B,* He S-H, Jiang Y,Chen T Q.*An efficient iodine pentoxide-triggered iodocarbocyclizations for the synthesis of iodooxindoles in water. Organic & Biomolecular Chemistry, 2018, 16, 5197-5202.

[47] Ye R Z, Cao Y J, Xi X X, Liu L, Chen T Q.* Metal- and radical-free aerobic oxidation of heteroaromatic methanes: an efficient synthesis of heteroaromatic aldehydes. Organic & Biomolecular Chemistry, 2019, 17, 4220-4224.

[48] Cao Y, Liu L, Huang T,Chen T Q.*Iodine-catalyzed a,b-dehydrogenation of ketones and aldehydes generating conjugated enones and enals. New Journal of Chemistry, 2020, 44, 8697-8701.

[49] Wang Q, Liu L, Dong J,*Chen T Q.*Metal-free thioesterification of amides generating acyl thioesters. New Journal of Chemistry, 2019, 43, 9384-9388.

[50] Xiao J, Yang J,Chen T Q,*Han L-B.* Nickel-Catalyzed α-Benzylation of Sulfones with Esters via C-O Activation. RSC Advances, 2016, 6, 42656 - 42659 (JCR一区, IF: 3.289).

[51] Li S,Chen T Q,*Saga Y, Han L-B.* Chloroform-Based Atherton-Todd-Type Reactions of Alcohols and Thiols with Secondary Phosphine Oxides Generating Phosphinothioates and Phosphinates. RSC Advances, 2015, 5, 71544-71546 (JCR一区, IF: 3.289).

[52]Chen T Q, Han L-B.* Optically Active H-Phosphinates and Their Stereospecific Transformations to Optically Active P-Stereogenic Organophosphoryl Compounds. Synlett, 2015, 26, 1153-1163 (Invited Review) (JCR二区, IF: 2.323, 2016年11月23日web of science数据显示该论文引用次数在该期刊自2015年以来发表论文中排名前17).

[53] Huang T-Z,Chen T Q,*Saga Y, Han L-B.* Me3P-catalyzed addition of hydrogen phosphoryl compounds P(O)H to electron-deficient alkenes: 1 to 1 vs 1 to 2 adducts. Tetrahedron, 2017, 73， 7085-7093 (JCR二区, IF: 2.651).

[54] Liu L, Yu W-Q, Huang T,Chen T Q.*Palladium-catalyzed alkynylation of aromatic amines via in situ formed trimethylammonium salts. Tetrahedron Letters, 2020, 61, 151647.

[55] Liu L, Xu K, Wang Y, Wang W., Xu H, Huang T,Chen T Q.*Palladium-catalyzed phosphorylation of benzyl ammonium triflates with P(O)H compounds. Tetrahedron, 2020, 76, 131020.

[56]Chen T Q,*Tan Q H, Liu X, Liu L, Huang T Z, Han L-B.* Phosphorylation of Carboxylic Acids and Their Derivatives with P(O)-H Compounds Forming P(O)-C Bonds. Synthesis, 2020, Accept.

[57] Yang J, Xiao J,Chen T Q,*Han L -B.* Nickel-Catalyzed Phosphorylation of Aryl Triflates with P(O)-H Compounds. Journal of Organometallic Chemistry, 2016, 820: 120-124 (JCR二区, IF: 2.336).

[58]Chen T Q, Xiao J, Zhou Y B, Yin S F, Han L -B.* Nickel-Catalyzed (E)-Selective Semihydrogenation of Internal Alkynes with Hypophosphorous Acid. Journal of Organometallic Chemistry, 2014, 749: 51-54 (Most downloaded JOMC articles in the first half yearof 2014) (JCR二区, IF: 2.336，2016年9月20日web of science数据显示该论文引用次数在该期刊自2014年以来发表论文中排名前20).

[59] Xiao J, Li Q,Chen T Q,*Han L -B.* Copper-Mediated Selective Aerobic Oxidative C3-Cyanation of Indoles with DMF. Tetrahedron Letters, 2015, 56: 5937-5940 (JCR二区, IF: 2.347).

[60] Lei J,† Su L B,† Zeng K,†Chen T Q,†Qiu R H, Zhou Y B, Au C-T, Yin S F,* Recent advances of catalytic processes on the transformation of alkynes into functional compound. Chemical Engineering Science, 2017, 171, 404-425 (invited review, †:并列第一作者).

[61]Chen T Q, Zhou Y B, Guo C C,* Han L -B.* Selective Addition of P(O)-H Bonds to Alkynes Catalyzed by Transition Metals Immobilized on Polystyrene-Bound Triphenylphosphine. Chemistry Letters, 2013, 42: 1065-1067 (JCR三区, IF: 1.550).

[62]Chen T Q, Zhou Y B, Yin S-F, Zhao Y L, Goto M, Han L -B.* Identification of Alkenyl and Arylpalladium Hydrides by the Aid of Hydrosilanes. Chemistry Letters, 2013, 42: 1227-1229 (JCR三区, IF: 1.550).

[63] Yang J, Xiao J, Zhou Y B,*Chen T Q,*Yin S F, Han L-B.* Recent Advances in the Synthesis of Organophosphorus Compounds via Cross Coupling between Readily Available Materials and P-H Compounds. Chinese Journal of Organic Chemistry, 2017, 37, 1055-1068(JCR三区, Invited review).

[64]Chen T Q,Liu L, Huang T, Han L-B. Synthesis and Reactivity of Group 10 Transition Metal Complexes with Alkenylphosphoryl Compounds. Chinese Journal of Organic Chemistry, 2019, 39, 2183-2187.

[65]Chen T Q,Han L-B.* Oxidative Addition of (RO)2P(O)H to Pt(0) Complexes Generating Pt-H Complexes: P(O)-H Bond Cleavage vs P(O-H) Bond Cleavage. Heteroatom Chemistry, 2018, e21460, DOI: 10.1002/hc.21460.

[66] Zhao Y L,Chen T Q,*Wang X B, Han L-B.* A Convenient Stereoselective Reduction of gem-Dibromides with a Combination of Dimethyl Phosphite and Potassium Carbonate. Phosphorus, Sulfur, and Silicon and the Related Elements, 2015, 190: 1820-1827 (JCR四区).