闻晓波
男，博士，中共党员；教授；博士/硕士研究生导师；
海南省拔尖人才；海南省地方猪产业技术体系岗位科学家
邮箱：xiaobo_wen@hainanu.edu.cn
通讯地址：海南省海口市美兰区人民大道58号，邮政编码：570228
研究领域
动物传染病的预防与控制
教育背景
2003年9月-2006年6月 中国农业科学院哈尔滨兽医研究所 预防兽医专业 博士
2000年9月-2003年6月黑龙江八一农垦大学 预防兽医专业 硕士
1996年9月-2000年6月黑龙江八一农垦大学 动物医学专业 学士
工作经历
2006年7月-2008年8月 黑龙江八一农垦大学动物科技学院 讲师
2008年9月-2008年12月 黑龙江八一农垦大学动物科技学院 副教授
2009年1月-2012年6月 美国国立卫生研究院（NIH） 博士后
2012年7月-2017年9月 黑龙江八一农垦大学动物科技学院 副教授
2017年9月-2019年10月 黑龙江八一农垦大学动物科技学院 教授
2019年11月-2023年8月 海南大学动物科技学院 教授
2023年9月-至今海南大学热带农林学院教授
讲授课程：
本科：兽医传染病学、兽医微生物学、兽医生物制品学、兽医学概论
研究生：兽医临床病例分析与研讨专题、文献解析专题、兽医生物制品学专题
科研项目
1.国家自然科学地区基金项目，轮状病毒NSP2、NSP5决定病毒质装配及RNA包装的关键互作位点定位及机制研究、2024/1-2027/12、32万元、在研、主持。
2.海南省农业农村厅，海南省地方猪现代农业产业技术体系专项，2022/1-2025/12、96万元。
3.海南大学科研启动项目，猪塞内卡病毒调控IFN信号转导通路及病毒致弱机制研究、2020/5-2025/5、100万元，在研，主持。
4.海南省自然科学基金项目，猪塞内卡病毒3C蛋白调控IFN信号转导通路的关键结构域及其作用机制、2020/12-2023/12、7万元，已结题，主持。
5.国家自然科学基金青年项目，牛UK株轮状病毒拮抗Ⅰ型IFN信号转导通路机制的研究、2013/1-2015/12、24万元、已结题、主持。
6.黑龙江省科学基金面上项目，异源宿主细胞内牛轮状病毒NSP1蛋白调控IFN免疫应答机制、2015/7-2018/7、10万元、已结题、主持。
7.博士后研究人员落户黑龙江科研启动资助项目，Caco-2细胞网格蛋白表达对轮状病毒侵入的影响、2014/1-2016/12、5万元、已结题、主持。
发表论文
[1] Zhao S M, Cui H Q, Hu Z R, Du L, Ran X H,Wen X B*. Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution [J]. Viruses-Basel, 2022, 14(5): 1055.
[2] Zhang X, Cui K,Wen X, Li L, Yu X, Li B, Lin H, He H, Wang F. The Association between Gut Microbiome Diversity and Composition and Heat Tolerance in Cattle [J]. Microorganisms, 2022, 10(8): 1672.
[3] Lv Q, Ran X, Qiu H, Zhao S, Hu Z, Wang J, Ni H,Wen X*. Seroprevalence of pullorum disease in chicken across mainland China from 1982 to 2020: A systematic review and meta-analysis [J]. Res Vet Sci, 2022, 152: 156-66.
[4] Yang Y, Teng Z, Lu Y, Luo X, Mu S, Ru J, Zhao X, Guo H, Ran X,Wen X*, Sun S*. Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants [J]. Res Vet Sci, 2021, 136: 89-96.
[5] Gong Q L, Chen Y, Tian T,Wen X, Li D, Song Y H, Wang Q, Du R, Zhang X X. Prevalence of bovine tuberculosis in dairy cattle in China during 2010-2019: A systematic review and meta-analysis [J]. PLoS Negl Trop Dis, 2021, 15(6): e0009502.
[6] Dong H, Lu Y L, Zhang Y, Mu S Y, Wang N, Du P, Zhi X Y,Wen X B, Wang X X, Sun S Q, Zhang Y M, Guo H C. A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity [J]. J Virol, 2021, 95(16): e0017721.
[7]Wen X, Tong X, Wang M, Wang J, Ni H, Ran X. Protective immunity following vaccination with a recombinant multiple-epitope protein of bovine herpesvirus type I in a rabbit model [J]. Appl Microbiol Biotechnol, 2020, 104: 3011-23.
[8] Ni H, Jia X X, Wang J, Ran X,Wen X*. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. Microb Pathog, 2020, 138: 103815.
[9] Mu S, Abdullah S W, Zhang Y, Han S, Guo H, Li M, Dong H, Xu J, Teng Z,Wen X, Sun S*. Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs [J]. Mol Cell Probes, 2020, 53: 101643.
[10] Lu Y, Dong H, Li J, Li L, Wang M, Liu H, Teng Z, Zhang Y, Jin Y, Guo H, Yang Y,Wen X*, Sun S*. Enhanced Protective Immune Response of Foot-and-mouth Disease Vaccine through DNA-loaded Virus-like Particles [J]. Microb Pathog, 2020, 143: 104130.
[11] Wang X, Bi Y, Ran X, Tong X, Ni H,Wen X*. Mapping a highly conserved linear neutralizing epitope on gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. J Vet Med Sci, 2019, 81(5): 780-6.
[12] Ran X, Yang Z, Bai M, Zhang Y, Wen X, Guo H, Sun S. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies [J]. Appl Microbiol Biotechnol, 2019, 103(7): 3015-24.
[13] Ran X, Meng X Z, Geng H L, Chang C, Chen X,Wen X*, Ni H*. Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice [J]. Microb Pathog, 2019, 132: 208-14.
[14] Ran X, Cheng J, Wang M, Chen X, Wang H, Ge Y, Ni H, Zhang X X*,Wen X*. Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis [J]. Acta Trop, 2019, 189: 117-23.
[15] Ran X, Chen X, Wang S, Chang C, Wen X, Zhai J, Ni H. Preparation of porcine enterotoxigenic Escherichia coli (ETEC) ghosts and immunogenic analysis in a mouse model [J]. Microb Pathog, 2019, 126: 224-30.
[16] Ran X, Chen X, Ma L,Wen X, Zhai J, Wang M, Tong X, Hou G, Ni H. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop, 2019, 190: 296-303.
[17] Ran X, Yang Z, Shao G,Wen X, Liu S, Ni H. Avian Salmonella enteritidis serovar Enteritidis with ClpP deletion is attenuated and highly immunogenic in chickens [J]. Turkish Journal of Veterinary and Animal Sciences, 2018, 42(4): 269-76.
[18] Ran X, Chen X, Wang M, Cheng J, Ni H, Zhang X X*,Wen X*. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis [J]. BMC Vet Res, 2018, 14(1): 393.
[19]Wen X, Sun J, Zhang Y, Cao S, Ran X, Ni H. Identification and genetic characterization of bovine parainfluenzavirus type 3 genotype c strain isolated from cattle in western China [J]. Turkish Journal of Veterinary and Animal Sciences, 2017, 41: 180-6.
[20]Wen X B, Jiang H T, Zhang Y L, Lang X Y, Liu J, Ni H B. Rapid and Sensitive Diagnosis of Cattle Anaplasmosis by Loop-Mediated Isothermal Amplification (LAMP) [J]. Pakistan Veterinary Journal, 2016, 36(2): 174-8.
[21]Wen X, Wei X, Ran X*, Ni H, Cao S, Zhang Y. Immunogenicity of porcine P[6], P[7]-specific truncated VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope [J]. Vaccine, 2015, 33(36): 4533-9.
[22]Wen X, Cao D, Jones R W, Hoshino Y, Yuan L. Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic [J]. Human vaccines & immunotherapeutics, 2015, 11(10): 2483-9.
[23] Ma Y,Wen X, Hoshino Y, Yuan L*. Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains [J]. Veterinary microbiology, 2015, 176(1-2): 172-8.
[24]Wen X, Wen K, Cao D, Li G, Jones R W, Li J, Szu S, Hoshino Y, Yuan L*. Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus DeltaVP8* subunit parenteral vaccines [J]. Vaccine, 2014, 32(35): 4420-7.
[25]Wen X, Cao D, Jones R W, Li J, Szu S, Hoshino Y*. Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [J]. Vaccine, 2012, 30(43): 6121-6.
[26] Long-Croal L M,Wen X, Ostlund E N, Hoshino Y*. Concentration of acrylamide in a polyacrylamide gel affects VP4 gene coding assignment of group A equine rotavirus strains with P[12] specificity [J]. Virology journal, 2010, 7: 136.
海南大学
