邓恒为

博士，副教授、硕士生导师

个人简介：

中山大学理学博士、博士后，海南自贸港E类人才。主要从事海洋动物分子免疫学及海洋生物病原分子生物学的研究。主持国家自然科学基金2项、广东省自然科学基金1项及海南大学启动基金1项，参与多项国家自然科学基金项目。发表论文18篇，其中SCI论文13篇，申请专利3项。

研究方向：

1. 甲壳动物抗病毒免疫分子机制

2. 水生动物先天性免疫调控机制

3. 病毒功能基因、致病机理及其与宿主的相互作用

研究项目：

1. 国自然地区科学基金，32260924，拟穴青蟹SOCS2介导的JAK/STAT通路负反馈环路及其对机体免疫稳态调控的分子机制，2023/01-2026/12，33万，主持

2. 国自然青年科学基金，32002440，拟穴青蟹干扰素调节因子调控干扰素诱导基因ISG12抗病毒的分子机制，2021/01-2023/12，24万，主持

3. 广东省自然科学基金面上项目，2022A1515010958，拟穴青蟹SOCS2负反馈调控JAK/STAT通路参与抗病毒免疫反应，2022/01-2024/12，10万，主持

4. 海南大学科研启动项目，拟穴青蟹干扰素诱导基因IFI27L2抗病毒的分子机制，2022/02-2027/02，24万，主持

5.福建省海洋渔业资源与生态环境重点实验室课题，JAK-STAT通路调控拟穴青蟹免疫稳态的分子机制及抗病毒效应，2023/10-2025/10，2万元，主持

6. 国家自然科学基金面上项目，32073004，p38 MAPK信号通路调控凡纳滨对虾血淋巴透明细胞吞噬功能活化的分子机制，2021/01-2024/12，58万，参与

7. 国家自然科学基金面上项目，31672677，青蟹呼肠孤病毒（MCRV）与青蟹双顺反子病毒（MCDV）共感染及相互影响机制，2017/01-2020/12，64万，参与

代表论文：

1.Hengwei Deng, Danrong Xian, Taixin Lian, Mingyu He, Jingjing Li, Xiaopeng Xu, Zhixun Guo, Jianguo He*, Shaoping Weng*, A Dicer2 fromScylla paramamosainactivates JAK/STAT signaling pathway to restrain mud crab reovirus, Developmental and Comparative Immunology, 127(2022)104267.

2.Hengwei Deng,Yeyu Li, Jinling Li, Wenjie Shen, Qiankang Chen, Shaoping Weng, Jianguo He, Xiaopeng Xu*, Neomycin inhibits Megalocytivirus infection in fish by antagonizing the increase of intracellular reduced glutathione, Fish & Shellfish Immunology, 127(2022), 148-154.

3.Hengwei Deng, Lei Hu, Jingjing Li, Wenyan Yan, Enhui Song, Mingqing Kuang, Shanshan Liu, Jianguo He*, Shaoping Weng*, The NF-κB family member dorsal plays a role in immune response against Gram-positive bacterial infection in mud crab (Scylla paramamosain), Developmental and Comparative Immunology,106 (2020) 103581.

4.Hengwei Deng, Wenfeng Zhang, Jingjing Li, Jinling Li, Lei Hu, Wenyan Yan, Shanshan Liu, Jianguo He*, Shaoping Weng*, A signal transducers and activators of transcription (STAT) gene fromScylla paramamosainis involved in resistance against mud crab reovirus, Fish and Shellfish Immunology,94 (2019) 580-591.

5.Hengwei Deng, Xiaopeng Xu, Lei Hu, Jingjing Li, Dandan Zhou, Shanshan Liu, Panpan Luo, Jianguo He*, Shaoping Weng*, A janus kinase fromScylla paramamosainactivates JAK/STAT signaling pathway to restrain mud crab reovirus, Fish and Shellfish Immunology,90 (2019) 275-287.

6.Deng Hengwei,Li Zhongbao*, Dai Gang, Yuan Yi, Ning Yefeng, Shangguan Jingbo, Huang Yesheng. Isolation of new polymorphic microsatellite markers from the marbled rockfishSebastiscus marmoratus. Genetics and molecular research, 14(2015): 758-762.

7.Wei-Liang Guo,Heng-Wei Deng, Fei Wang, Shi-Feng Wang, Zhi-Hong Zhong, Yun Sun, Xue-Fen Chen, Jin-Hua Wang, Yong-Can Zhou*.In vitroandin vivoscreening of herbal extracts againstStreptococcus agalactiaein Nile tilapia (Oreochromis niloticus). Aquaculture 503 (2019) 412-421.

8.Jiefeng Gao^#, Ran Geng^#,Hengwei Deng, Hongliang Zuo, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A novel Forkhead box protein P (FoxP) from Litopenaeus vannamei plays a positive role in immune response. Frontiers in Immunology, 11(2020):593987.

9.Shoujia Jiang^#, Lijun Fu^#, Zijian Gao,Hengwei Deng, Yong Zhang, Xinxin You, Qiong Shi, Danqi Lu*. Multi-Omics Study on the Molecular Mechanisms of Tetraodon Nigroviridis Resistance to ExogenousVibrio ParahaemolyticusInfection. Frontiers in Marine Science. 9(2022):914028.

10.邓恒为,郭伟良,孙晓飞,等.响应面法优化丹参中抗无乳链球菌活性成分的提取工艺[J].渔业科学进展, 2014,35(4):132-140.

11.邓恒为,周永灿,郭伟良,等.抗哈氏弧菌中草药筛选及其活性成份提取工艺的优化[J].水产科学, 2013, 32 (5):249-255.

12. 胡蕾,邓恒为,李晶晶,刘姗姗,何建国,李海云,翁少萍.拟穴青蟹Cactus基因的cDNA克隆、序列及生物学功能[J].水产学报,2020,44(01):21-32.

联系方式

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