· 海南大学
学科建设
    病原真菌致病机制及控制团队(负责人:柳志强)
    2022年03月28日 17:58

团队负责人

柳志强,博士,教授,博士生导师,海南省BJ人才,主讲微生物学、微生物学实验、基因工程实验等课程。目前主要从事病原真菌致病机制及防控,热带微生物资源开发与利用等相关研究,先后主持国家自然科学基金3项,海南省重点研发计划1项,海南省自然科学基金2项,参与国家科技支撑计划、国家自然科学基金、农业农村部农产品风险评估项目等多项,在国内外期刊发表学术论文50余篇,其中SCI论文20余篇。

团队介绍

围绕危害动、植物及人类生命健康的重要病原真菌,系统研究病原真菌形态建成及致病相关基因的功能,解析相关次级代谢产物的合成机制,揭示其致病的分子机制,并针对病原真菌筛选有效的控制方法。本团队现有成员4人,其中教授2人,副研究员1人,实验师1人,海南省BJ人才2人。团队先后主持国家自然科学基金5项,海南省重点研发计划,高层次人才项目及海南省自然科学基金等多项,近5年发表SCI论文30余篇。

团队成员

李晓宇,张双飞,唐雯

主要研究方向

1、病原真菌分子致病机制及防控技术

2、病原真菌形态建成及调控机制

3、病原真菌次级代谢产物解析及调控机制

近期研究成果

[1]Jiujuan Zhao, Jinhua Sun, Min Li, Deqiang Gong, Jinyu Yang, Ying He, Zhiqiang Liu*, Meijiao Hu*. First report of anthracnose caused byColletotrichum karstiionDalbergia odoriferain China. Plant Disease, 2024, 108: 222.

[2]Jing Gao, Shuangzhen Zhou, Wen Tang, Jinhong Wang, Huanqing Liu, Ying Zhang, Liya Wang, Xiaoyu Li*, Zhiqiang Liu*. The velvet proteins CsVosA and CsVelB coordinate growth, cell wall integrity, sporulation, conidial viability and pathogenicity in the rubber anthracnose fungusColletotrichum siamense. Microbiological Research, 2023, 268: 127290.

[3]Diguang Wang, Ying Zhang, Shuangzhen Zhou, Xingyuan Zhang, Shayu Liu, Xiaoyu Li*, Zhiqiang Liu*. Gcc1 homologs regulate growth, oxidative stress, conidiation and appressorium formation inColletotrichum siamenseandColletotrichum graminicola. Microbial Pathogenesis, 2023, 182: 106249.

[4]Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu*, Jae-Hyuk Yu*. The putative C2H2 transcription factor VadH governs development, osmotic stress response, and sterigmatocystin production inAspergillus nidulans. Cells, 2022, 11, 3998.

[5]Jinhong Wang, Rui Wang, Jing Gao, Huanqing Liu, Wen Tang, Zhiqiang Liu, Xiaoyu Li*. Identification of threeStreptomycesstrains and their antifungal activity against the rubber anthracnose fungusColletotrichum siamense. Journal of General Plant Pathology, 2023, 89: 67-76.

[6]Shumin Wang, Meijiao Hu, Xiangxiang Qu, Jinyu Yang, Zhaoyin Gao, Shuming Wang, Zhiqiang Liu*, Min Li*. First report ofColletotrichum queenslandicumcausing leaf anthracnose onDracaena cambodianain China. Journal of General Plant Pathology, 2022,88:344-348.

[7]Xiaoyu Li, Zhijian Ke, Shuang Xu, Wen Tang , Zhiqiang Liu*. The G-protein alpha subunit CgGa1 mediates growth, sporulation, penetration and pathogenicity inColletotrichum gloeosporioides. Microbial Pathogenesis, 2021, 161: 105254.

[8] Xiaoyu Li, Yateng Wu, Zhiqiang Liu*. Antifungal activity of an endophytic fungusAspergillus versicolorDYSJ3 fromAphanamixis grandifoliaBlume againstColletotrichum musae. Mycobiology, 2021, 49(5): 498-506.

[9]Xiaoyu Li, Shayu Liu, Nan Zhang, Zhiqiang Liu*. Function and transcriptome analysis of an oligopeptide transporter CgOPT2 in the rubber anthracnose fungusColletotrichum gloeosporioides. Physiological and Molecular Plant Pathology, 2021, 115: 101661.

[10] Kai Zhang, Liushuang Gu, Yuefeng Zhang, Zhiqiang Liu*,Xiaoyu Li*. Dinactin from a new producer,Streptomyces badiusgz-8, and its antifungal activity against the rubber anthracnose fungusColletotrichum gloeosporioides. Microbiological Research, 2020, 240: 126548.

[11] Liushuang Gu, Kai Zhang, Nan Zhang,Xiaoyu Li*, Zhiqiang Liu*. Control of the rubber anthracnose fungusColletotrichum gloeosporioidesusing culture filtrate extract fromStreptomyces deccanensisQY-3. Antonie van Leeuwenhoek, 2020, 113: 1573-1585.

[12]Xiaoyu Li, Zhijian Ke, Xinjun Yu, Zhiqiang Liu*, Chenghui Zhang. Transcription factor CgAzf1 regulates melanin production, conidial development and infection inColletotrichum gloeosporioides. Antonie van Leeuwenhoek, 2019: 112: 1095-1104.

主持科研项目

1. 柳志强,Homeobox型转录因子CgAfh1调控胶孢炭疽菌附着胞发育及侵染的分子机制,国家自然科学基金地区基金项目,2022/01-2025/12,34万元,项目编号:32160041

2. 李晓宇,橡胶炭疽病菌致病相关转录因子CgCon7的靶基因鉴定及调控机制,国家自然科学基金地区基金项目,2022/01-2025/12,35万元,项目编号:32160371

3. 李晓宇,暹罗炭疽菌Velvet蛋白CsVeA调控分生孢子发生及侵染的分子机制,海南省自然科学基金高层次人才项目,2024/03-2026/02,10万元,项目编号:324RC449

代表性成果介绍

1. 解析了暹罗炭疽菌Velvet蛋白CsVosA-CsVelB的调控功能及分子机制



2. 解析了构巢曲霉C2H2型转录因子VadH的生物学功能及调控机制





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