(照片)姓 名:张睿佳
职 称:副研究员
导师类别:硕士生导师
E-mail:zhanglicai.hi@163.com
一、个人基本情况
2020年博士毕业于中山大学。研究方向为典型/新型环境化学污染物毒性评价新技术的开发和环境化学污染物的健康危害效应及分子毒理机制研究。以独立第一作者身份在Journal of Hazardous Materials, Environment International, Trends in Analytical Chemistry等发表SCI学术论文9篇。主持国家自然科学基金青年项目,中国博士后面上项目,广东省自然科学基金等5个项目。曾获2021年度 “广东省青年优秀人才国际培养计划博士后项目” 。
二、教育工作情况
2024.01-至今:海南大学,生命健康学院,副研究员
2022.08-2023.12:中山大学,特聘副研究员
2020.07-2022.07:中山大学,博士后,合作导师:余世孝 教授
2017.09-2020.06:中山大学,博士研究生,导师:栾天罡 教授
2014.09-2017.06:南方医科大学,硕士研究生,导师:马安德 教授
2009.09-2014.06:南方医科大学,本科
三、研究领域
环境化学污染物的健康危害,代谢毒性,代谢流,
四、代表性项目
【1】国家自然科学基金青年项目,建立环境代谢流量组学用于环境健康研究(No. 22206207),2023.01-2025.12,30万,主持
【2】广东省自然科学基金面上项目,全氟辛酸及其替代物引起胰岛β细胞代谢重构的研究(2022A1515011916),2022.01-2024.12,10万,主持
【3】广州市基础与应用基础研究项目,无机砷暴露影响结直肠癌细胞迁移过程的代谢调控,2024.04-2026.03,5万,主持
【4】中国博士后基金面上项目,全氟辛酸及其替代物造成3D胰岛β细胞球的代谢毒性及机制研究(2021M693596),2022.01-2023.12,8万,主持,已结题
【5】中央高校基本科研业务费项目,基于3D肝细胞球研究全氟化合物替代物的代谢毒性机制(22qntd2613),2022.01-2022.12,7.45万,主持,已结题
五、代表性成果
【1】Zhang Ruijia, Tu Lanyin, Yang Yuanzhu, Sun Jin, Liang Tong, Li Yizheng, Chen Ruohong, Chen Baowei*, Luan Tiangang*, Altered generation pattern of reactive oxygen species triggering DNA and plasma membrane damages to human liver cells treated with arsenite,Science of the Total Environment,2023.11.20, 900, 165821 (IF2022= 9.8).
【2】Zhang Ruijia, Lu Wenhua, Tu Lanyin, Lin Yingshi, Sun Jin, Chen Baowei*, Luan Tiangang, Perfluorooctanoic acid-induced metabolic disorder via enhancing metabolism of glutamine in human intestinal cells,Environmental Pollution,2023.10.4, 338, 122684 (IF2022= 8.9).
【3】Zhang Ruijia, Sun Jin, Tu Lanyin, Lu Wenhua, Li Yizheng, Luan Tiangang, Chen Baowei*, Constructing interactive networks of functional genes and metabolites to uncover the cellular events related to colorectal cancer cell migration induced by arsenite,Environment International(0160-4120),2023.05.21, 174, 107860 (IF2022= 11.8).
【4】Zhang Ruijia, Chen Baowei*, Zhang Hui, Tu Lanyin, Luan Tiangang*, Stable isotope-based metabolic flux analysis: A robust tool for revealing toxicity pathways of emerging contaminants,Trends in Analytical Chemistry,2023.02.12, 159, 116909 (IF2022= 13.1).
【5】Zhang Ruijia, Lu Wenhua, Yao Yao, Tu Lanyin, Yu Tiantian, Luan Tiangang*, Chen Baowei*, Metabolomics analysis of the 3D L-02 cell cultures revealing the key role of metabolism of amino acids in ameliorating hepatotoxicity of perfluorooctanoic acid,Science of the Total Environment,2022.02.01, 806, 150438 (IF2022= 9.8).
【6】Zhang Ruijia, Yao Yao, Tu Lanyin, Luan Tiangang*, Chen Baowei*, Non-targeted metabolomics of multiple human cells revealing differential toxic effects of perfluorooctanoic acid,Journal of Hazardous Materials, 2021.05.05, 409, 125017 (IF2022= 13.6).
【7】Zhang Ruijia, Chen Baowei*, Lin Li, Zhang Hui, Luan Tiangang*, (13)C isotope-based metabolic flux analysis revealing cellular landscape of glucose metabolism in human liver cells exposed to perfluorooctanoic acid,Science of the Total Environment,2021.05.20, 770, 145329 (IF2022= 9.8).
【8】Zhang Ruijia, Zhang Hui, Chen Baowei*, Luan Tiangang*, Fetal bovine serum attenuating perfluorooctanoic acid-inducing toxicity to multiple human cell lines via albumin binding,Journal of Hazardous Materials,2020.05.05, 389, 122109 (IF2022= 13.6).
【9】Zhang Ruijia, Ye Jufeng, Wei Qinzhi, Li Minjie, Xu Kaihui, Li Zihuan, Lin Wenting, Liu Peishan, Chen Ruopei, Ma Ande*, Zhou Zhifeng*, Plasma concentration of 14 perfluoroalkyl acids (PFAAs) among children from seven cities in Guangdong, China,Science of the Total Environment,2018.03, 616-617, 1469.