姓　名：盛夏

职　称：教授

导师类别：博士生导师、硕士生导师

E-mail：xsheng@hainanu.edu.cn

一、个人基本情况

国家重点研发计划青年科学家，海南大学C类人才，环境应激与健康稳态团队负责人

二、教育情况

2005–2009北京林业大学，生物科学国家理科基地班，学士

2009–2012北京林业大学，生物学院，硕士

2010–2011比利时安特卫普大学，生物医学院，硕士交换

2013–2016挪威奥斯陆大学，生命科学学院，博士

三、科研情况

以通讯/第一作者在Nature Communications、Advanced Science、EMBO Molecular Medicine、Oncogene、Theranostics等领域高水平期刊发表论文20余篇，累计引用1500余次，谷歌学术H=21

四、研究领域

主要从事环境应激与健康稳态调控方向的研究，聚焦内质网响应环境刺激、调控健康稳态、参与疾病发生发展的作用机制与靶向干预价值。

五、代表性项目

2023–2027海南大学高层次人才启动项目，主持

2022–2027科技部重点研发计划青年科学家项目，主持

六、代表性成果

1. Zhang T^#, Zhao F^#, Zhang Y^#, Shi JH, Cui F, Ma W, Wang K, Xu C, Zeng Q, Zhong R, Li N, Liu Y, Jin Y,Sheng X*. Targeting the IRE1α-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling.Oncogene.2024.

2. Zhang T^#, Zhao F^#*, Lin Y, Liu M, Zhou H, Cui F, Jin Y, Chen L,Sheng X*. Integrated analysis of single-cell and bulk transcriptomics develops a robust neuroendocrine cell-intrinsic signature to predict prostate cancer progression.Theranostics.2024; 14(3): 1065-1080.

3. Xiao R^#, You L^#, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G*,Sheng X*, Sun C*. Inhibiting the IRE1α axis of the unfolded protein response enhances the anti-tumor effect of AZD1775 in TP53 mutant ovarian cancer.Advanced Science. 2022;9(21): e2105469.

4. Shi C^#, Zhao F^#, Zhang T^#, Xu D, Hao Z, Cui F, Shi JH, Jin Y, Li N, Yang C, Zhang Y*,Sheng X*. A novel prognostic signature in osteosarcoma characterized from the perspective of unfolded protein response.Clinical and Translational Medicine. 2022; 12: e750.

5. Wang G^#, Zhang M^#, Meng P^#, Long C^#, Luo X^#, Yang X, Wang Y, Zhang Z, Mwangi J, Kamau PM, Dai Z, Ke Z, Zhang Y, Chen W, Zhao X, Ge F, Lv Q, Rong M, Li D, Jin Y*,Sheng X*, Lai R*. Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis.Acta Pharmaceutica Sinica B. 2022; 12(5): 2268-2279.

6. Cui F^#, Pan Q^#, Wang S, Zhao F, Wang R, Zhang T, Song Y, He J, Zhang H, Weng Q, Jin Y, Xia W, Li Y, Yang GY, De Vos W, Timmermans JP, Xu S*, Tang Y*,Sheng X*. Maternal benzophenone exposure impairs hippocampus development and cognitive function in mouse offspring.Advanced Science. 2021; 8(23): e2102686. (封面故事)

7. Zhang T, Li N, Sun C, Jin Y,Sheng X*. MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?EMBO Molecular Medicine.2020; 12(5): e11845.

8. Zhang W, Liu W, Bao S, Liu H, Zhang Y, Zhang B, Zhou A, Chen J, Hao K, Xia W, Li Y,Sheng X*, Xu S*. Association of adverse birth outcomes with prenatal uranium exposure: A population-based cohort study.Environment International.2020; 135: 105391.

9.Sheng X, Nenseth HZ, Qu S, Kuzu OF, Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, Mills IG, Danielsen H, Theis F, Patterson JB, Jin Y, Saatcioglu F. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.Nature Communications.2019; 10(1): 323. (Nature Reviews Urology研究亮点，ESI高被引)

10. Wang Y, Wang K, Jin Y,Sheng X*. Endoplasmic reticulum proteostasis control and gastric cancer.Cancer Letters. 2019; 449: 263-271.

11.Sheng X^#, Arnoldussen YJ^#Storm ML^#, Tesikova M, Jin Y, Nenseth HZ, Zhao S, Mills IG, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen HE, Hotamisligil GS, Saatcioglu F. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.EMBO Molecular Medicine. 2015; 7(6): 788-801.

12.Sheng X, Zhang H, Weng Q. Traditional Chinese medicine: China's bear farms prompt public outcry.Nature. 2012; 484(7395): 455. (评论文章)

七、举办学术会议

大会负责人，2021年内质网蛋白稳态与疾病国际学术会议。2021年10月，湖北武汉。