(照片)姓 名:万心怡
职 称:教授
导师类别:博士生导师、硕士生导师
E-mail:xwan@hainanu.edu.cn
一、个人基本情况
万心怡,女,博士,教授。海南大学高层次引进人才。
二、教育工作情况
教育经历:
(1) 2014-09至2019-03,爱丁堡大学,细胞与分子生物学,博士
(2) 2012-09至2013-09,伦敦帝国理工学院,免疫学,硕士
(3) 2008-09至2012-07,北京林业大学,生物科学,学士
工作经历:
(1) 2022-12至 今,海南大学,生命科学学院,教授
(2) 2018-10至2022-11,爱丁堡大学,生物科学学院,博士后研究员
(3) 2017-09至2018-08,爱丁堡大学,生物科学学院,硕士课程指导教师
三、教学情况
现代微生物学专题(硕士课程)
四、科研情况
2014年开始从事微生物传感器研究,利用合成生物学工具为大肠杆菌设计、构建、优化微生物传感器用于环境和健康相关的污染物、病原体等检测。近5年以第一作者(含共一)发表5篇相关论著于Nature Chemical Biology,Nature Communications,Analytical Chemistry等国际著名期刊。
五、研究领域
主要研究兴趣:环境与健康领域相关的微生物传感技术研究与应用。
六、代表性项目
Wellcome Trust, Institutional Translational Partnership Award, PIII080, New portable CRISPR-enabled RNA sensor for rapid SARS-CoV-2 detection, 2020-07至2021-07, 18万元,主持(已结题)
七、代表性成果
(其余研究成果请见https://orcid.org/0000-0002-5250-9277)
(1) Yang Liu; Filipe Pinto#;Xinyi Wan#; Zhugeng Yang; Shuguang Peng; Mengxi Li; Jonathan M. Cooper; Zhen Xie; Christopher E. French; Baojun Wang; Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors,Nature Communications, 2022, 13:1937
(2)Xinyi Wan; Behide Saltepe; Luyang Yu; Baojun Wang; Programming living sensors for environment, health and biomanufacturing,Microbial Biotechnology, 2021, 14(6): 2334-2342
(3)Xinyi Wan; Filipe Pinto; Luyang Yu; Baojun Wang; Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity,Nature Communications, 2020, 11:5961
(4)Xinyi Wan; Trevor Y. H. Ho; Baojun Wang; Engineering Prokaryote Synthetic Biology Biosensors,Handbook of Cell Biosensors, Springer, Cham., 2019
(5)Xinyi Wan; Francesca Volpetti; Ekaterina Petrova; Chris French; Sebastian J.Maerkl; Baojun Wang; Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals,Nature Chemical Biology, 2019, 15: 540-548
(6) Antonia Lopreside#;Xinyi Wan#; Elisa Michelini; Aldo Roda; Baojun Wang; Comprehensive profiling of diverse genetic reporters with application to whole-cell and cell-free biosensors,Analytical Chemistry, 2019, 91(23): 15284-15292
(7) Yang Liu;Xinyi Wan; Baojun Wang; Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria,Nature Communications, 2019, 10: 3693
(8)Xinyi Wan; Yilin Huo; Michael Johns; Emma Piper; Justin C. Mason; David Carling; Dorian O. Haskard; Joseph J. Boyle; 5'-AMP–Activated Protein Kinase–Activating Transcription Factor 1 Cascade Modulates Human Monocyte–Derived Macrophages to Atheroprotective Functions in Response to Heme or Metformin,Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33: 2470-2480
八、荣誉奖励
荣获英国2022年SWIG Early Career Researcher Competition一等奖(英国水传感器青年科学家竞赛最高奖项)。