研究方向:
1.有机磷化合物新的合成方法及其机理研究
2.过渡金属催化反应及其应用研究
3.药物分子与功能材料的设计开发
讲授课程:《化工热力学》、《化工过程分析与综合》、《精细化学品与工艺学》、《化工原理实验》、《生产实习》、《毕业实习》
学术成就: 海南自由贸易港D类人才,在Green Chem.、J. Org. Chem.、Organometallics、Dalton Trans.等国际高水平期刊发表SCI论文十余篇;主持国家自然科学基金青年基金项目、海南省自然科学基金青年基金项目、海南省自然科学基金高层次人才项目、海南大学科研启动经费等。
主要从事有机杂原子化合物新的合成方法及其机理研究、过渡金属催化反应及其应用研究。
科研项目:
1.国家自然科学基金青年基金项目,2023.01.01-2025.12.31,主持。
2.海南省自然科学基金高层次人才项目,2022.01.01-2024.12.30,10万元,主持。
3.海南省自然科学基金青年基金项目,2021.09-2024.06,5万元,主持。
4.海南大学科研启动基金项目,2020.11-2025.11,10万元,主持。
5. 国家级大学生创新训练项目,廉价金属催化醇和P(O)–H化合物脱水偶联合成含P–C键有机磷化合物研究,2021-2022,结题,指导老师。
6. 国家级大学生创新训练项目,过渡金属催化羧基导向C–H键活化构建C–P键反应的研究,2023-2024,在研,指导老师。
论著专利:
1.Chunya Liand Li-Biao Han*. Palladium-catalyzed solvent-free preparation of arylphosphonates ArP(O)(OAr)2from (ArO)3P via the Michaelis–Arbuzov rearrangement.Organometallics,2020,39, 3613-3617.
2.Chunya Li,Yuta Saga, Shun-ya Onozawa, Shu Kobayashi, Kazuhiko Sato, Norihisa Fukaya, and Li-Biao Han*. Wet and dry processes for the selective transformation of phosphonates to phosphonic acids catalyzed by Brønsted acids.J. Org. Chem.,2020,85, 14411–14419.
3.Chunya Li,Qi Wang, Jian-Qiu Zhang, Jingjing, Ye, Ju Xie, Qing Xu* and Li-Biao Han*. Water determines the products: an unexpected Brønsted acid-catalyzed PO-R cleavage of P(III) esters selectively producing P(O)–H and P(O)–R compounds.Green Chem.,2019,21, 2916-2922.
4.Chunya Li,Tieqiao Chen* and Li-Biao Han*. Iron-catalyzed clean dehydrogenative coupling of alcohols with P(O)–H compounds: a new protocol for ROH phosphorylation.Dalton Trans.,2016,45, 14893-14897.
5.Jian-Qiu Zhang, Jingzhuo Zhao,Chunya Li, Jingjing Ye, Li-Biao Han*.Conversion of
α‐hydroxy(2,4,6‐trimethylbenzyl)diphenylphosphine oxide to TPO: oxidationvsdecomposition.Phosphorus, Sulfur, and Silicon and the Relat. Elem.,2021,196, 207-210.
6. Kang Xiang, Shuo Zhang, Long Liu, Tianzeng Huang, Zhi Tang, Chunya Li, Kaiqiang Xua, Tieqiao Chen*.Tunable C–H arylation and acylation of azoles with carboxylic acids by Pd/Cu cooperative catalysis.Org. Chem. Front.,2021,8, 2543-2550.
7. Xinyi Li, Long Liu, Tianzeng Huang, Zhi Tang,Chunya Li, Wenhui Li, Tao Zhang, Zhaohui Li, Tieqiao Chen*. Palladium-catalyzed decarbonylative sonogashira coupling of terminal alkynes with carboxylic acids.Org. Lett.,2021,23, 3304-3309.
8. Xue Liu, Long Liu, Tianzeng Huang, Jingjing Zhang, Zhi Tang,Chunya Li, Tieqiao Chen*. Trifluoromethylation of benzoic acids: an access to aryl trifluoromethyl ketones.Org. Lett.,2021,23, 4930-4934.
9. Yuanyuan Tang, Kuan Liu, Jinjin Zhang, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*. Palladium-catalyzed stereoselective difunctionalization of bicyclic alkenes with organoammonium salts and organoboronic compounds.J. Org. Chem.,2021,86, 11937-11947.
10. Tao Zhang, Kunyu Wang, Yuting Ke, Yuanyuan Tang, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*. Transition-metal-free and base promoted C–C bond formation via C–N bond cleavage of organoammonium salts.Org. Biomol. Chem.,2021,19, 8237-8240.
11. Ying Lin, Dongyang Li, Jingjing Zhang, Zhi Tang*, Long Liu, Tianzeng Huang,Chunya Li, Tieqiao Chen*. I2/NaH2PO2-mediated deoxyamination of cyclic ethers for the synthesis of N-aryl-substituted azacycles. New J. Chem.,2021,45, 21011-21014.
12. Kuan Liu, Bin Song, Qi Dang, Long Liu*, Jie Tang, Tianzeng Huang,Chunya Li, Zhi Tang, Tieqiao Chen*.Walking Cations: Transition-Metal Free Benzyl Cation-Triggered sp2 C—H Phosphorylation and Etherification.Chin. J. Chem.,2022,40, 2933-2938.
13. Tianhao Xu, Xingyu Zhou, Xiong Xiao, Yan Yuan, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang and Tieqiao Chen*.Nickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols.J. Org. Chem.,2022,87, 13, 8672-8684.
14. Tianhao Xu, Wenhui Li, Kang Zhang, Yuhui Han, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang, and Tieqiao Chen*.Palladium-Catalyzed Decarbonylative Cyanation of Carboxylic Acids with TMSCN.J. Org. Chem.,2022,87, 11871-11879.
15. Tianhao Xu, Xiangbing Zhou, Yuhui Han, Liangwei Zhang, Long Liu, Tianzeng Huang,Chunya Li, Zhi Tang, Shungang Wan*, Tieqiao Chen*. Palladium-catalyzed stereo-selective three-component cis-1,2-arylalkynylation of bicyclic alkenes with aryltriflates and terminal alkynes.Tetrahedron Let.,2022,97,153799.
16. Tao Zhang, Runji Wang, Jiani Chen, Long Liu*, Tianzeng Huang,Chunya Li, Zhi Tang and Tieqiao*. Base-promoted direct E-selective olefination of organoammonium salts with sulfones toward stilbenes and conjugated 1,3-dienes.Org. Biomol. Chem.,2022, 20, 4369-4375.
17. 李春娅,甘立广,樊晓璐,徐乐杰,陈铁桥,刘龙,黄添增,唐智. 一种有机膦氧类化合物及其合成方法,2023,专利,授权。
合作交流:
1.Chunya Li,Li-Biao Han.Water determines the selectivity: facile room temperature C-O cleavage of P(III) esters by Brønsted acids leading to a mild and efficient halide-Free Michaelis–Arbuzov rearrangement.日本化学会第99春季年会, 2019.03.16-2019.03.19(Oral Presentation).
2. Chunya Li, Li-Biao Han. Brønsted acid-catalyzed hydrolysis of phosphonates to phosphonic acids.日本第46回有機典型元素化学討論会, 2019.12.05-2019.12.07(Poster Presentation).