曹文薰 女 博士

电子邮箱：996838@hainanu.edu.cn

1.教育背景

2013.09-2017.06 沈阳药科大学 药物制剂 学士

2017.09-2018.06 西南交通大学 药学 硕博连读

2018.09-2024.06 西南交通大学 材料科学与工程 博士

2.科研情况

主要从事有机和无机纳米生物材料制剂的研究及设计，通过跨学科构建系列智能响应型的微纳米载体应用于心血管疾病的诊疗研究。近五年来在Chemical Engineering Journal、Advanced Functional Materials、ACS Applied Materials & Interfaces、Acta Biomaterialia等国际重要期刊上发表多篇SCI论文，其中第一作者发表的SCI论文4篇。

3.研究领域

通过智能响应型的微纳米载体实现心血管疾病的诊疗研究。

4.代表性成果

（1）Cao WX^#, Wei W^#, Qiu B, Liu Y, Xie S, Fang QB, Li XH*. Ultrasound-powered hydrogen peroxide-responsive Janus micromotors for targeted thrombolysis and recurrence inhibition, Chemical Engineering Journal, 2024, 483: 149187. IF=15.1 (一区)

（2）Cao WX, Xie S, Liu Y, Ran P, Zhang ZL, Fang QB, Li, XH*. Shear stress-triggered theranostic nanoparticles for piezoelectric-Fenton photodynamic thrombolysis and endogenous thrombus imaging, Advanced Functional Materials, 2024, 34: 2312866. IF=19 (一区)

（3）Cao WX, Liu Y, Ran P, He J, Xie S, Weng J*, Li XH*. Ultrasound-propelled Janus rod-shaped micromotors for site-specific sonodynamic thrombolysis. ACS Applied Materials & Interfaces, 2021, 13: 58411-58422. IF=9.5 (二区)

（4）Ran P^#,Cao WX^#, Zheng H, Xie S, Zhang GY, Liu Y, Li XH*. Intrabacterial nitroreductase-activated imaging and persistently illuminated photodynamic therapy for intracellular infection theranostics, Advanced Functional Materials, 2024, 2402731. IF=19 (一区)

（5）Zhang ZL^#, Yan H^#,Cao WX, Xie S, Ran P, Wei K, Li XH*. Ultrasound-chargeable persistent luminescence nanoparticles to generate self-propelled motion and photothermal/NO therapy for synergistic tumor treatment. ACS Nano, 2023, 17: 16089-16106. IF=17.1 (一区)

（6）Xie SZ^#,Mo CF^#,Cao WX, Xie S, Li S, Zhang ZL, Li XH*. Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic Agents. Acta Biomaterialia, 2022, 142: 49-59. IF=9.7 (一区)

（7）Xie SZ^#, Li S^#,Cao WX, Mo CF, Zhang ZL, Huang K, Li XH*. Bacteria-templated and dual enzyme-powered microcapsule motors to promote thrombus penetration and thrombolytic efficacy. ACS Applied Materials & Interfaces, 2021, 14: 37553-37565. IF=9.5 (二区)

（8）Xie S^#, Li Y^#,Cao WX, Peng JW, Huang K, Meng J, Li XH*. Dual-responsive nanogels with cascaded gentamicin release and lysosomal escape to combat intracellular small colony variants for peritonitis and sepsis therapies. Advanced Healthcare Materials, 2024, 2303671. IF=10 (二区)

（9）Ran P, Zheng H,Cao WX, Jia XW, Zhang GY, Liu Y, Li XH*. On-demand changeable theranostic hydrogels and visual imaging-guided antibacterial photodynamic therapy to promote wound healing. ACS Applied Materials & Interfaces, 2021, 14: 49375-49388. IF=9.5 (二区)

（10）He J^#, Ran P^#, Cheng MH,Cao WX, Xie S, Zhang GY, Li XH*. Intracellular infection-responsive release of no and peptides for synergistic bacterial eradication. Journal of Controlled Release, 2022, 352: 87-97. IF=10.8 (一区)