· 海南大学
研究生教育
    宋英奇
    2023年12月29日 14:55


宋英奇博士 副教授 硕士生导师

电子邮箱:996548@hainanu.edu.cn

1.教育背景

2020.09-2023.10 澳门大学 生物医药 哲学博士

2017.09-2020.07 四川大学 药理学专业 理学硕士

2013.09-2017.07 山西中医药大学 药学专业 理学学士

2.科研情况

主要围绕抗肿瘤和抗炎等疾病相关模型开展药物发现、药物设计、靶向蛋白降解、蛋白——蛋白相互作用、诊疗一体化等方向研究,以第一作者或共同第一作者在Chemical Engineering Journal, Medicinal Research Reviews, British Journal of Pharmacology, Journal of Pharmaceutical Analysis, Chinese Chemical Letters, Bioorganic Chemistry等高水平期刊发表多篇SCI论文。

3.研究领域

1)药物发现:基于高通量筛选技术发现具有抗肿瘤/抗炎活性的药物

2)药物设计:PROTAC药物分子设计和合成新方法研究

4.代表性成果

1)YQ Song#, KJ Wu#, ZM Zhang, TM Liu, CN Ko, WG Zhu, DL Ma*, WH Wang*, CH Leung*. Development of a sensitive luminescent probe to uncover new BRD4 inhibitors in living cells.Chemical Engineering Journal.2023, 463: 142356.(IF = 16.744,中科院1区)

2)YQ Song, GD Li, D Niu, F Chen, SZ Jing, KW Wong, WH Wang*, CH Leung*. A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance.Journal of Pharmaceutical Analysis.2023.(IF = 14.026,中科院1区)

3)YQ Song, GJ Yang*, DL Ma, WH Wang*, CH Leung*. The role and prospect of lysine-specific demethylases in cancer chemoresistance.Medicinal Research Reviews.2023, 1-32.(IF = 12.388,中科院1区)

4)YQ Song, C Wu, KJ Wu, QB Han, XM Miao, DL Ma*, CH Leung*. Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer.Frontiers in Cell and Developmental Biology.2021, 9: 665646. (IF = 6.684,中科院2区)

5)ML Guo#,YQ Song#, JF Cheng, GQ Dong, Xun Sun*, CQ Sheng*. Hydrophobic tagging-induced degradation of NAMPT in leukemia cells.Chinese Chemical Letters, 2023: 109392.(IF = 9.1, 中科院1区)

6)GJ Yang#,YQ Song#, WH Wang, QB Han, DL Ma*, CH Leung*. An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells.Bioorganic Chemistry, 2021, 114: 105158.(IF = 5.307,中科院1区)

7)LT Liu#,YQ Song#, XS Chen#, Y Liu, JJ Zhu, LM Zhou, SJ Xu, LH Wan*. Morphine‐induced RACK1‐dependent autophagy in immortalized neuronal cell lines.British Journal of Pharmacology, 2020, 177(7): 1609-1621.(IF = 9.473,中科院1区)

8)R Li#,YQ Song#, ZN Ji, L Li*, LM Zhou*. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses.Biofactors, 2020, 46(1): 158-167.(IF = 6.438,中科院2区)

9)SS Cheng, GJ Yang, WH Wang,YQ Song, Ko CN, QB Han, DL Ma*and CH Leung*. Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor against metastasis in triple-negative breast cancer cells.Acta Materia Medica1, 2, 197-211.

10)HX Xie, LS Yang, Q Hu,YQ Song, XY Wang, LM Zhou*, LJ Li*. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate‐binding protein‐interacting protein 1 in tongue cell carcinoma.Head & Neck, 2020, 42(12): 3623-3637.

11)R Li, XY Ma,YQ Song, YY Zhang, WB Xiong, L Li*, LM Zhou*. Anti‐colorectal cancer targets of resveratrol and biological molecular mechanism: analyses of network pharmacology, human and experimental data. Journal of Cellular Biochemistry, 2019, 120(7): 11265-11273.

12)宋英奇, 马帅静, 晏晓杰,等. 氧化白藜芦醇对肝癌细胞增殖、迁移、侵袭和自噬的研究[J]. 中药药理与临床, 2018, 34(6):46-50.(中文核心)

13)张媛媛,宋英奇. 文献报告在药理学化疗药理教学中的应用[J].四川生理科学杂志, 2018, 40(03):71-73.


欢迎医学、药学等相关及交叉学科研究背景的同学报考本课题组研究生!

欢迎本科生来课题组开展科研学习!

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