石东磊男 博士 副研究员 硕士生导师

电子邮箱：996476@hainanu.edu.cn;1119212452@qq.com

2023年7月通过高层次人才引进到海南大学药学院工作。

1.教育背景

2011.09-2015.06 黑龙江大学 制药工程 学士

2016.09-2019.06 西北大学 材料工程 硕士

2020.09-2023.06 华东理工大学 药学 博士

2. 科研情况

积极响应国家健康中国战略，应对人口老龄化中长期规划，聚焦衰老及相关疾病的精准诊断与治疗前沿，开展衰老进程精准识别探针分子与诊疗一体化药物分子研发。一方面，设计合成衰老进程精准识别探针分子，用以可视化研究衰老发生机制，辅助抗衰老药物研发；设计合成实用型衰老识别探针，构建药物筛选平台，高通量、快捷评价、筛选抗衰老药物。另一方面基于衰老进程发生机制，设计合成诊疗一体化抗衰老药物分子，精准可视化靶向作用于衰老细胞，延缓机体衰老进程、治疗衰老相关疾病。以第一/共一/共通作者身份在Nature Aging、Chemical Science、Sensorsandactuators B-Chemical等期刊发表论文9篇，申请发明专利5项。

3. 研究领域

衰老及相关疾病的精准可视化诊疗

[1] 有机小分子荧光探针的设计合成：研究衰老相关疾病发生机制、评价抗衰老药物药效，辅助抗衰老药物研发

[2] 光激活精准诊疗一体化senolytic/senomorphic前药分子的研发：基于衰老相关疾病的特异性标志物及发病机制，设计合成可视化精准衰老进程调控/衰老相关疾病治疗药物

4.代表性成果

[1]Donglei Shi†; Wenwen Liu†; Ying Gao†; …; Yuan Guo*; Jian Li*, Photoactivatable senolysis with single-cell resolution delays aging,Nat. Aging,2023,3, 297-312. (SCI, IF = 16.6, JCR一区; Research Briefing,Nat. Aging,2023, 3, 244-245；News & Views,Nat. Chem.,2023,15, 451-452.)

[2]Donglei Shi†; Shuqiang Chen†; Biao Dong†; ...; Yuan Guo*, Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe,Chem. Sci.,2019,10, 3715-3722. (SCI, IF = 8.4, 中科院大类一区, 他引91次)

[3]Donglei Shi†; Linghao Hu†; Xinming Li†; …; Yuan Guo*, Jian Li*, Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe,Sens. Actuators B,2020,319, 128302.(SCI, IF = 8.4, 中科院大类一区, 他引17次)

[4]Donglei Shi†; Wenwen Liu†; Guangwei Wang; Yuan Guo*; Jian Li*, Small-molecule fluorescence-based probes for aging diagnosis,Acta Materia Medica,2022, 1, 4-23

[5] Jingye Tian†;Donglei Shi† (Co-first author); Yanhui Zhang†; …; Jian Li*; Yuan Guo*, Stress response decay with aging visualized using a dual-channel logic based fluorescent probe,Chem. Sci.,2021,12, 13483-13491. (SCI, IF = 8.4, 中科院大类一区, 他引17次)

[6] Huan Wang†;Donglei Shi† (Co-first author); …; Jian Li; Yuan Guo*, A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells,Sens. Actuators B,2018,256, 600-608. (SCI, IF = 8.4, 中科院大类一区, 他引62次)

[7] Linghao Hu†;Donglei Shi† (Co-first author); Xinming Li†; …; Yuan Guo*; Jian Li*, Curcumin-based polarity fluorescent probes: Design strategy and biological applications,Dyes Pigments,2020,177, 108320. ( SCI, IF = 4.5, 中科院大类二区, 他引28次)

[8] Yihe Song†; Xinming Li†;Donglei Shi† (Co-first author); …; Yuan Guo*; Jian Li*, A senolysis-based theragnostic prodrug strategy towards chronic renal failure,Chem. Sci.,2022,13, 11738-11745. (SCI, IF = 9.969, 中科院大类一区)

[9] Liangliang Gao; Shuli Pan; Ying Gao;Donglei Shi* (Co-corresponding author); Yuan Guo*, Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine,Advanced Agrochem,2022,1, 22-38.

5.荣誉奖励

[1] 入选2021年华东理工大学“张江树优博”培育计划

[2] 上海市优秀毕业生（2023年）

欢迎具有药物化学/化学、生物学背景的同学报考本课题组研究生。