宋施豪男 博士副研究员博（硕）士生导师

电子邮箱：songsh@hainanu.edu.cn

1.教育背景

2018.6–2020.6:南洋理工大学，理学院，博士联合培养

2018.9–2021.6:华南农业大学，植物保护学院，博士

2021.6–2022.9:中山大学，药学院（深圳），博士后

2022.9–至今:海南大学，药学院，副研究员

2.科研情况

主持国家自然科学基金青年基金、博士后面上项目和高校基本科研业务费项目，作为科研骨干参与一项国家重点研发计划。以第一作者或通讯作者在国际高水平SCI期刊如Nature Communications,PLOS Pathogens，CCS Chemistry，ISME Journal，Virulence，Molecular Plant Pathology等发表论文13篇（中科院一区7篇），同时已授权国家发明专利16项。

3.研究领域

病原细菌信号调控与致病机理

病原细菌-宿主互作机制研究

新型抗菌药物研制及作用机理研究

4.代表性项目

1）国家自然科学基金青年项目，金额30万，主持，2024年，在研。

2）博士后面上项目，金额：8万，主持，2022年，结题。

3）中央高校基本科研业务费，金额：5万，主持，2022年，结题。

4）国家重点研发专项“变革性技术关键科学问题”—高通量培养筛选鉴定健康相关微生物的关键技术，金额：2374万，课题骨干，2021年，在研。

5.代表性成果

1) Xu Y^#,Song S^#, Duan H, Deng Y*, Liu XW*. (2024). Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan: Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs.CCS Chemistry, 6:1-10.(IF:11.2,中科院1区)

2) Li X^#, Yin W^#, Lin JD^#, Zhang Y, Guo Q, Wang G, Chen X, Cui B, Wang M, Chen M, Li P, He YW, Qian W, LuoH, ZhangLH, Liu XW*,Song S*, Deng Y*. (2023). Regulation of the physiology and virulence ofRalstonia solanacearumby the second messenger 2',3'-cyclic guanosine monophosphate.Nature Communications14(1):7654.(IF: 16.6,中科院1区)

3)Song S^#,*, Zhao S^#, Sun X^#, Meng L, Wang Z, Tan H, Liu J, Zhang M, Deng Y*. (2023). Anti-virulence strategy of diaryl chalcogenide compounds againstCandida albicansinfection.Virulence14(1):2265012.(IF = 5.2,中科院1区)

4) Huang J^#,Song S^#,*, Zhao S, Sun X, Wang Z, Huang X, Xiao Q, Deng Y*. (2023). Anti-virulence activity of novel (1-heteroaryloxy-2-hydroxypropyl)-phenylpiperazine derivatives against both wild-type and clinical drug-resistantCandida albicansstrains.Microbial Biotechnology16(1):116-127.(IF:5.7,中科院2区)

5)Song S, Sun X, Guo Q, Cui B, Zhu Y , Li X, Zhou J, Zhang LH, Deng Y*. (2022). An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity ofRalstonia solanacearum.PLoS Pathogens18(5): e1010562.(IF:6.7,中科院1区)

6) Ye P^#, Li X^#, Cui B^#,Song S^#, Shen F, Chen X, Wang G, Zhou X, Deng Y*. (2022). Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors.Communications Biology5:496.(IF:5.9,中科院1区)

7) Wang M^#, Li X^#,Song S^#, Cui C, Zhang LH, Deng Y*. (2022). The cis-2-dodecenoic acid (BDSF) quorum sensing system inBurkholderia cenocepacia.Applied and Environmental Microbiology88(4):e0234221.(IF:4.4,中科院2区)

8)Song S^#, Sun X^#, Meng L, Wu Q, Wang K, and Deng Y*. (2021) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents againstCandida albicans.Microbial Biotechnology14(2):430-443. (IF:5.7,中科院2区,Highlight byMicrobial Biotechnology2020, 13, 1702-1704)

9)Song S^#, Yin W^#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*. (2020) Anthranilic acid fromRalstonia solanacearumplays dual roles in intraspecies signalling and inter-kingdom communication.ISME Journal14:2248-2260.(IF:11.0,中科院1区)

10) Shen F^#, Yin W^#,Song S^#, Zhang Z, Ye P, Zhang Y, Zhou J, He F*, Li P*, and Deng Y*. (2020)Ralstonia solanacearumpromotes pathogenicity by utilizing L-glutamic acid from host plants.Molecular Plant Pathology21:1099-1110.(IF:4.9,中科院1区)

11) Cui C^#,Song S^#, Yang C^#, Sun X, Huang Y, Li K, Zhao S, Zhang Y, and Deng Y*. (2019) Disruption of Quorum Sensing and Virulence inBurkholderia cenocepaciaby a Structural Analogue of the cis-2-Dodecenoic Acid Signal.Applied and Environmental Microbiology85(8):e00105-19.(IF:4.6,中科院2区)

12)Song S^#, Fu S^#, Sun X^#, Li P, Wu J, Dong T, He F and Deng Y*. (2018) Identification of Cyclic Dipeptides fromEscherichia colias New Antimicrobial Agents againstRalstonia solanacearum.Molecules23(1):214.(IF:4.6,中科院2区)

13) Cui C^#, Yang C^#,Song S^#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity inBurkholderia cenocepacia.Molecular Microbiology108: 32-44.(IF:3.6,中科院2区)

6.荣誉奖励

深圳市海外高层次C类人才

海南省高层次人才