程仲彬 男 理学博士 副教授 硕士生导师

邮箱:czb360@126.com/chengzhongbin@hainanu.edu.cn

1.教育背景

2021.05-2022.08河南大学药学院副教授

2017.08-2021.04河南大学药学院讲师

2014.09-2017.06北京大学药学院生药学

2011.09-2014.06中山大学药学院生药学

2007.09-2011.06中山大学药学院药学

2.研究方向: 天然药物化学

药用植物和海洋真菌活性成分发现

3.科研简介

在Journal of Natural Products（9篇第一或独立通讯，IF 5.10）、Bioorganic Chemistry(IF 5.1)、Marine Drugs(IF 5.4)、Phytochemistry等领域内SCI期刊发表研究性论文40余篇，被引750余次、H-指数20。其中第一或通讯作者论文20余篇。BioorgChem、Fitoterapia、NatProd Res常邀审稿人。主持和参与多项国家级项目。曾获中国药学会优秀论文二等奖、河南省科技进步二等奖。中国菌物学会海洋与淡水菌物学专业委员会委员，MarineDrugs客座编辑。

4.承担项目

1)国家自然科学基金青年项目，81903536，深海土曲霉中a-葡萄糖苷酶抑制剂的发现、结构优化及构效关系研究,2020/01-2022/12,结项，主持

2)中国博士后科学基金第63批面上一等资助，2018M630815，海洋真菌PD-E1的次生代谢产物及其抗食管癌活性研究，2018/01-2020/12,结项，主持

3)河南省青年托举工程项目，2020HYTP059，托姆青霉Penicillium thomii中色原酮类抗炎成分的发现及作用机制研究，2020/01-2021/12,结项，主持

4)国家自然科学基金-国际合作，21861142006，抗多重耐药病原菌和生物膜新型海洋天然产物发现及分子机制研究，2019/01-2022/12，参与

5)国家自然科学基金面上项目，81872793，抗HBV病毒新型海洋briarane萜类分子发现与作用机制研究，2019/01-2022/12，参与

6)国家自然科学基金-河南联合基金，U1804176，茄呢醇衍生物的合成及其胶束作为活性药物载体的协同抗肿瘤作用.2019/01-2021/12,参与

7)国家自然科学基金面上项目，81573326，海绵内生放线菌以ent-cpp为前体的二萜类天然产物的发现及生物合成途径中的二萜合成酶的特征研究，2016/01-2019/12,参与

8)国家自然科学基金青年项目，21502004，化学诱变海洋真菌WGC-25C-6突变株中混源倍半萜生物碱的结构多样性与抗流感活性研究，2016/01-2018/12,参与

5.代表性成果

[1] Z.Zhang^#, Y.Li^#, H. Wang, W.Xu, C.Wang, H.Ma, F.Zhong, J.Ou, Z. Luo, H-B Luo,Z.Cheng*. Ergone derivatives from the deep-sea-derived fungusAspergillusterreusYPGA10 and 25,28-dihydroxyergone-induced apoptosis in human colon cancer SW620 Cells.Journal of Natural Products,2024 (In press, DOI:/10.1021/acs.jnatprod.4c00154).

[2] S. Han^#, Huabin Ma^#, Y. Wu, Y. Li, C. Wang, Q. Li,Z.Cheng*. Andrastin-type meroterpenoids, sesquicarane-type sesquiterpenoids, and penipyrols from the red pine seed-derived fungusPenicilliumsp.Phytochemistry,2024 (Accepted).

[3] Y. Lu, X. Zhao, M. Yuan, M. Zhao, K. Liu, M. Zhang, X. Qiu, X. Yu*, X. Liu*, D. Wei, J. Xie,Z. Cheng*. KYNU expression promotes cisplatin resistance in esophageal cancer,Journal of Cancer,2024, 15, 2475-2485.

[4] Y.Li^#, J.Shi^#, R.Liu, Y.Liu, R.Liu, Z.Wu, W.Xu, H.Ma, H-B Luo,Z.Cheng*. Structure revisions of phenolic bisabolane sesquiterpenes and a ferroptosis inhibitor from the marine-derived FungusAspergillus versicolorYPH93.Journal of Natural Products2023, 86, 830-841. (cited times: 7)

[5] W. Liu, Y. Liu, F. Yang, S. Han, J. Zhang, H. Yang*,Z. Cheng*, Q. Li*. Asperflaloids A and B fromAspergillus flavipesDZ-3, an endophytic fungus ofEucommia ulmoidesOliver,Molecules, 2021, 26, 3514. (cited times:8)

[6] S. Han, Y. Liu, W. Liu, F. Yang, J. Zhang, R. Liu, F. Zhao*, W. Xu*,Z. Cheng*. Chromone derivatives with α-glucosidase inhibitory activity from the marine fungusPenicillium thomiiMaire,Molecules,2021, 26, 5273.

[7] Q. Li^#, W. Xu^#, R. Fan^#, J. Zhang, Y. Li, X. Wang, S. Han, W. Liu, M. Pan,Z. Cheng*. Penithoketone andpenithochromones A–L,polyketides from the deep-sea-derived fungusPenicillium thomiiYPGA3,Journal of Natural Products2020, 83, 2679–2685. (cited times: 22)

[8] Y. Li^#, W. Liu^#, S. Han, J. Zhang, W. Xu, Q. Li,Z. Cheng*. Penitholabene, a rare 19-nor labdane-type diterpenoid from the deep-sea-derived fungusPenicillium thomiiYPGA3,Fitoterapia,2020, 146, 104691. (cited times: 13)

[9]Z. Cheng*,W. Liu, R. Fan, S. Han, Y. Li, X. Cui, J. Zhang, Y. Wu, X. Lv, Y. Zhang, Z. Luo, S.A. Alias, W. Xu*, Q. Li*. Terpenoids from the deep-sea-derived fungusPenicillium thomiiYPGA3 and their bioactivities,Marine Drugs2020, 18, 164. (cited times:11)

[10]Z. Cheng*, Y. Li, W. Xu, W. Liu, L. Liu, D. Zhu, Y. Kang, Z. Luo, Q. Li*. Three new cyclopiane-type diterpenes from a deep-sea derivedPenicilliumsp. YPGA11 fungus and their effects against human esophageal carcinoma cells.Bioorganic Chemistry2019, 91, 103129. (cited times: 33)

[11]Z. Cheng^#,W. Xu^#, Y. Wang, S. Bai, L. Liu, Z. Luo, W. Yuan*, Q. Li*.Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungusPenicilliumsp. YPGA11.Fitoterapia,2019, 133, 120-124. (cited times: 37)

[12]Z. Cheng^#,Y. Li^#, W. Liu, L. Liu, J. Liu, W. Yuan*, Z. Luo, W. Xu*, Q. Li*. Butenolide derivatives with α-glucosidase inhibitions from the deep-sea-derived fungusAspergillus terreusYPGA10.Marine Drugs2019, 17, 332. (cited times:23).

[13]Z. Cheng^#,W. Xu^#, L. Liu, S. Li, W. Yuan, Z. Luo, J. Zhang, Y. Cheng, Q. Li*. Peniginsengins B–E, New farnesylcyclohexenones from the deep sea-derived fungusPenicilliumsp. YPGA11.Marine Drugs2018, 16, 358. (cited times:16).

[14]Z. Cheng^#, D. Liu^#, W. Cheng, P. Proksch, W. Lin*.Versiquinazolines L–Q, new polycyclic alkaloids from the marine-derived fungusAspergillus versicolor.RSC Advances2018, 8, 31427-31439. (cited times:16).

[15] Wei, Yunlong^#; Wang, Chao^#;Cheng, Zhongbin^#(co-first author),et al. Heterodimeric diterpenoids isolated from euphorbia ebracteolata roots and their inhibitory effects on α-glucosidase.Journal of Natural Products,2017, 80, 3218-3223.(cited times: 39)

[16]Z. Cheng, L. Lou, D. Liu, X. Li, P. Proksch, S. Yin, W. Lin*. Versiquinazolines A-K, Fumiquinazoline-type alkaloids from the gorgonian-derived fungusAspergillus versicolorLZD-14-1.Journal ofNaturalProducts,2016,79, 2941-2952.(cited times: 43)

[17]Z. Cheng, J. Zhao, D. Liu, P. Proksch, Z. Zhao*, W. Lin*. Eremophilane-type sesquiterpenoids from anAcremoniumsp. fungus isolated from deep-sea sediments.Journal ofNaturalProducts2016, 79, 1035-1047.(cited times: 37)

[18]Z.-B. Cheng^#, X. Lu^#, J.-M. Bao, Q.-H. Han, Z. Dong, G.-H. Tang, L.-S. Gan*, H.-B. Luo*, S. Yin*.(±)-Torreyunlignans A-D, rare 8-9¢linked neolignan enantiomers as phosphodiesterase-9A inhibitors fromTorreya yunnanensis.Journal ofNaturalProducts,2014, 77 (12), 2651-2657.(cited times: 20)

[19]Z.-B. Cheng^#, Y.L. Deng^#, C.Q. Fan, Q.H. Han, S.L. Lin, G.H. Tang, H.B. Luo*, S. Yin*. Prostaglandin derivatives: Nonaromatic phosphodiesterase-4 inhibitors from the soft coralSarcophyton ehrenbergi.Journal of Natural Products,2014, 77, 1928-1936.(cited times: 23)

[20]Z.B. Cheng^#, W.W. Shao^#, Y.N. Liu, Q. Liao, T.T. Lin, X.Y. Shen, S. Yin*. Extracellular signal-regulated kinases (ERK) inhibitors fromAristolochia yunnanensis.Journal of Natural Products,2013,76, 664-671.(cited times: 23)

[21]Z.B. Cheng, H. Xiao, C.Q. Fan, Y.N. Lu, G. Zhang, S. Yin*. Bioactive polyhydroxylated sterols from the marine spongeHaliclona crassiloba.Steroids,2013, 78, 1353-1358. (citedtimes:31).