徐从军博士 副教授 博士研究生导师

邮箱：congjunxu@hainanu.edu.cn；congjunxu@163.com

2018年毕业于沈阳药科大学获得博士学位，随后进入中山大学药学院进行博士后研究工作，2021年11月通过高层次人才引进到海南大学工作。

1.教育背景与科研经历

2018.09—2021.08，中山大学， 药学院，博士后；

2015.09—2018.06，沈阳药科大学， 制药工程，博士；

2012.09—2015.06，沈阳药科大学， 药物化学，硕士；

2008.09—2012.06，长春工业大学， 制药工程，学士；

2.科研情况

致力于创新小分子药物的研究，在抗药物设计、合成以及生物评价方面积累了丰富的经验。近年来聚焦医学前沿领域，结合化学生物学和分子生物学等学科技术在抗肿瘤药物研究领域开展了一系列基础与应用研究。近五年科研成果突出，已发表SCI论文10余篇，主持科研项目3项。

3.研究领域

抗肿瘤药物；

神经退行性疾病创新药物设计与发现；

前药设计及靶向递送

4.社会兼职

担任J Med Chem等药物化学杂志审稿人，中国化学会会员，中国抗癌协会会员

5.代表性项目

1）国家自然科学基金青年项目，82204193，30万元，主持；
2）广东省基础与应用基础研究基金区域联合基金（省部级），2020A1515110522，10万元，主持；
3）广东省自然科学基金面上项目,2022A1515012527,10万元，主持；
4）海南省自然科学基金面上项目，822MS052，8万元，主持；
5）中山大学青年教师培育项目，19ykpy122， 15万元，主持；

6.代表性成果

1）Yong Rao*#, Rui Su#, Chenyan Wu#, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhikai Guo,Congjun Xu*, Ling Huang*, Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling. Acta Pharmaceutica Sinica B, 2023 . (SCI, IF14.5000，中科院大类一区)

2）Xu, Congjun*; Han, Yufei; Xu, Sicong; Wang, Ruxin; Yue, Ming; Tian, Yu; Li, Xiaofan; Zhao, Yanfang*; Gong, Ping*; Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker, European Journal of Medicinal Chemistry, 2020, 186: 111867. (SCI, IF7.0878，中科院大类一区)；

3）Mingze Qin*, Yangyang Meng, Haoshen Yang, Lei Liu, Haotian Zhang, Simeng Wang, Chunyang Liu, Xia Wu, Di Wu, Ye Tian, Yunlei Hou, Yanfang Zhao, Yajing Liu,Congjun Xu*, Lihui Wang*, Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. Journal of Medicinal Chemistry, 2021, 64, 5519–5534 (SCI，IF8.0385，中科院大类一区)；

4）Yifeng Shen#,Congjun Xu#, Jie Chen#, Zilin Guan, Yanjuan Huang, Zishan Zeng, Xiaoyu Xu, Xiaomin Tan, and Chunshun Zhao*. Photo-triggered self-adaptive “Nano-chameleon”：A Functionalized MOCs-based Drug Delivery Platform Promises high anti-tumor efficacy. Advanced Healthcare Materials. 2021, 10, 2100676. (SCI，IF11.0926，中科院大类一区)；

5）Congjun Xu‡, Zhanghong Xiao‡, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, yuanfeng He,Yuqi Gao, Chunshun Zhao*. Discovery of A Potent Glutathione Peroxidase 4 Inhibitor as Selective Ferroptosis Inducer. Journal of Medicinal Chemistry,2021,64,13312−13326. (SCI，IF8.0385，中科院大类一区)；

6）Congjun Xu#, Haolan Yang#, Tao Zhang, Zilin Guan, Jie Chen, Hualu Lai, Xiaoyu Xu, Yanjuan Huang, Zeqian Huang, Chunshun Zhao* Reduction-responsive Dehydroepiandrosterone Prodrug Nanoparticles Loaded with Camptothecin for Cancer Therapy by Enhancing Oxidation Therapy and Cell Replication Inhibition. International Journal of Pharmaceutics. 2021, 603, 120671(SCI，IF 5.875,中科院大类二区，药学一区);

7）Xu Congjun; Han Yufei; Chen Shaowei; Xu Dengzhi; Zhang Bingfu; Shan Zhenliang; Du Shimei; Xu Liying*; Gong Ping*; One-pot synthesis of 2-methyl-1,5-diaromatic-1H-pyrroles from styrene, acetone and arylamines using TBHP, copper(II) trifluoromethanesulfonate and sulfamic acid, Tetrahedron Letters, 2018, 59(3): 260-263.(SCI，IF 2.415,中科院大类三区)；

8）Xu Congjun#; Qin Mingze#; Yi Jun; Wang Yanjing; Chen Yanfeng; Zhang Bingfu; Zhao Yanfang*; Gong Ping*; Copper(II)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling, RSC Advances, 2017, 7(40): 24643-24646.(SCI，IF 3.361,中科院大类三区)；

9）Huang, Zeqian#; Wei, Gaofei#; Zeng, Zishan; Huang, Yanjuan; Huang, Liangfeng; Shen, Yifeng; Sun, Xiaoqi;Xu, Congjun; Zhao, Chunshun*; Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor, Theranostics, 2019, 9(19): 5542-5557.(SCI, IF 11.556,中科院大类一区)；

10）Huang, Yanjuan#; Jiang, Yali#; Xiao, Zhanghong#; Shen, Yifeng; Huang, Liangfeng,; Xu, Xiaoyu; Wei, Gaofei;Xu, Congjun;Zhao, Chunshun*; Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion, Chemical Engineering Journal, 2019, 380(2020): 122369-122383.(IF 13.273,中科院大类一区)；

11.）Lu, Kuan; Cai, Lude; Zhang, Xue; Wu, Guodong;Xu, Congjun; Zhao, Yanfang; Gong, Ping* Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors. Bioorganic Chemistry, 2018, 76, 528–537.(IF 5.275,中科院大类一区)。

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