黄仪有博士 研究员 博士/硕士生导师

邮箱：742646380@qq.com

1.教育背景及工作经历

2021. 09 – 海南大学药学院，研究员

2020. 09 – 2021. 08 中山大学药学院，特聘副研究员

2018. 09 – 2020. 08 中山大学药学院，博士后

2015. 09 – 2018. 06 中山大学药学院，药物化学博士

2011. 09 – 2014. 06 中山大学药学院，药物化学硕士

2007. 09 – 2011. 06 南方医科大学药学院，药学学士

2.科研情况

利用X射线晶体学等结构生物学技术手段，解析药物靶标的三维结构，并以靶标为中心开展药物设计和药物化学等药学研究，特别是围绕磷酸二酯酶(PDEs)及其选择性抑制剂的开发等进行相关研究。主持国家自然科学基金面上项目、国家自然科学基金青年基金、海南省自然科学基金面上项目等6项基金，并在国内外重要学术期刊如Proc Natl Acad Sci USA、JMed Chem、Acta Pharm Sin B、Org Lett等发表SCI论文30余篇，其中（并列）一作/（共同）通讯论文有18篇，授权发明专利4项。

3.研究领域

结构生物学及基于靶标结构的药物设计

4.代表性项目

1)国家自然科学基金面上项目，2023-2026，主持

2)国家自然科学基金青年基金，2021 – 2023，主持

3)海南省自然科学基金面上项目，2022-2024，主持

4)海南大学科研启动经费，2021 – 2026，主持

5)中国博士后科学基金面上资助，2019 – 2020，主持

6)中山大学高校基本科研业务费青年教师培育项目，2018 – 2021，主持

5.代表性成果

1）Deyan Wu^#, Xuehua Zheng^#, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang,Yi-You Huang^*, Hai-Bin Luo^*. Free energy perturbation (FEP)-guided scaffold hopping.Acta Pharm. Sin. B.2022,12: 1351-1362.

2）Yuncong Yang^#, Sirui Zhang^#, Qian Zhou^#, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu,Yi-You Huang^*, Lei Guo^*, Hai-Bin Luo^*. Discovery of Highly Selective and Orally Available Benzimidazole-based Phosphodiesterase 10Inhibitors with Improved Solubility and Pharmacokinetic Properties for Treatment of Pulmonary Arterial Hypertension.Acta Pharm. Sin. B.2020,10:2339-2347.

3）Haobai Liu^#, Quan Wang^#, Yue Huang^#, Jinhui Deng, Xi Xie , Jiaqi Zhu , Yijun Yuan , Yue-Ming He,Yi-You Huang^*, Hai-Bin Luo^*, Xixin He^*. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.Eur. J. Med. Chem.2022,242:114631.

4）Feng Zhou^#, Yue Huang^#, Lu Liu^#, Zhendong Song, Ke-Qiang Hou, Yifan Yang, Hai-Bin Luo,Yi-You Huang^*, Xiao-Feng Xiong^*. Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.Biochem. Pharmacol.2022,202:115123.

5）Yi-You Huang^#, Jinhui Deng^#, Yi-Jing Tian^#, Jinhao Liang, Xi Xie, Yue Huang, Jiaqi Zhu, Ziran Zhu, Qian Zhou, Xixin He^*, Hai-Bin Luo^*.Mangostanin Derivatives as Novel and Orally Active PDE4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.J. Med. Chem.2021.64, 13736-13751.

6）Yi-You Huang^#,Yan-Fa Yu^#, Chen Zhang^#, Yiping Chen, Qian Zhou, Zhuoming Li, Sihang Zhou, Zhe Li, Lei Guo, Deyan Wu^*, Yinuo Wu^*, Hai-Bin Luo^*. Validation of Phosphodiesterase-10as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.J. Med. Chem.2019,62: 3707-3721.

7）Zhendong Song^#,Yi-You Huang^#, Ke-Qiang Hou^#, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo^*, Xiao-Feng Xiong^*. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.J. Med. Chem.2022,65: 4238-4254.

8）Jinhao Liang^#,Yi-You Huang^#,Qian Zhou^#, Yuqi Gao, Zhe Li, Deyan Wu, Si Yu, Lei Guo, Zhen Chen, Ling Huang, Steven H. Liang, Xixin He^*, Ruibo Wu^*, Hai-Bin Luo^*. Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4Inhibitors for the Treatment of Vascular Dementia.J. Med. Chem.2020,63: 3370-3380.

9）Zhe Li^#,Yi-You Huang^#, Yinuo Wu, Jingyi Chen, Deyan Wu, Chang-Guo Zhan^*, Hai-Bin Luo^*. Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10.J. Med. Chem.2019,62: 2099-2111.

10）Zhe Li^#, Xin Li^#,Yi-You Huang^#, Yaoxing Wu, Runduo Liu, Lingli Zhou, Yuxi Lin, Deyan Wu, Lei Zhang,Hao Liu, Ximing Xu, Kunqian Yu, Yuxia Zhang, Jun Cui^*, Chang-Guo Zhan^*, Xin Wang^*, Hai-Bin Luo^*. Identify Potent SARS-CoV-2 Main Protease Inhibitors via Accelerated Free Energy Perturbation-based Virtual Screening of Existing Drugs.Proc. Natl. Acad. Sci. USA.2020, 117: 27381-27387.

11）Yi-You Huang^#, Xin Liu^#, Deyan Wu, Guihua Tang, Zengwei Lai, Xuehua Zheng^*, Sheng Yin^*, Hai-Bin Luo^*. The Discovery, Complex Crystal Structure, and Recognition Mechanism of a Novel Natural PDE4Inhibitor from Selaginella pulvinata.Biochem. Pharmacol.2017,130: 51-59.

12）Yi-You Huang, Zhe Li, Yinghong Cai, Lingjun Feng, Yinuo Wu, Xingshu Li, Hai-bin Luo^*. The Molecular Basis for the Selectivity of Tadalafil Toward Phosphodiesterase 5 and 6: a Modeling Study.J. Chem. Inf. Model.2013,53: 3044-3053.

13）Yan-Fa Yu^#, Chen Zhang^#,Yi-You Huang^#, Sirui Zhang, Qian Zhou, Xiangmin Li, Zengwei Lai, Zhe Li, Yuqi Gao, Yinuo Wu, Lei Guo^*, Deyan Wu^*, Hai-Bin Luo. Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10Inhibitors.ACS Chem. Neurosci.2020,11: 1058-1071.

14）Xiaoxia Qiu^#,Yiyou Huang^#,Deyan Wu, Fei Mao, Jin Zhu, Wenzhong Yan^*, Hai-bin Luo^*, Jian Li^*. Discovery of Novel Purine Nucleoside Derivatives as Phosphodiesterase 2(PDE2) Inhibitors: Structure-based Virtual Screening, Optimization and Biological Evaluation.Bioorgan. Med. Chem.2018,26: 119-133.

15）Ting Yao^#,Yiyou Huang^#, Meng Zhang, Yujuan Chen, Hairun Pei, Jianyou Shi*, Huanchen Wang^*, Yousheng Wang^*, Hengming Ke^*. Crystal Structures of Candida Albicans Phosphodiesterase 2and Implications for Its Biological Functions.Biochemistry,2018,57: 6070-6077.

16）Tingting Lin^#,Yiyou Huang^#,Guihua Tang, Zhongbin Cheng, Xin Liu, Hai-bin Luo^*, Sheng Yin^*. Prenylated Coumarins: Natural Phosphodiesterase-4Inhibitors from Toddalia Asiatica.J. Nat. Prod.2014,77: 955-962.

17）Yena Liu^#,Yiyou Huang^#, Jingmei Bao, Yinghong Cai, Yanqiong Guo, Shaonan Liu, Hai-bin Luo^*, Sheng Yin^*. Natural Phosphodiesterase-4(PDE4) Inhibitors from Crotalaria Ferruginea.Fitoterapia, 2014,94: 177–182.

18）Jiasheng Zhong^#,Yiyou Huang^#, Wenjing Ding, Xiaofang Wu, Jinzhi Wan^*, Hai-bin Luo^*. Chemical Constituents of Aloe Barbadensis Miller and Their Inhibitory Effects on Phosphodiesterase-4D.Fitoterapia,2013,91: 159-165.

欢迎有药学、生物学、化学等相关学科背景的同学报考本课题组的博士/硕士研究生。