On October 28th, the 2022 International Genetically Engineered Machine Competition (iGEM) was held in Paris, France. As the first team of our university to participate in the event, the team (HainanU_China), with the strong support of the State Key Laboratory of Marine Resources Utilization in the South China Sea and other relevant units and departments, competed with 350 teams from MIT, Harvard University, Tsinghua University, Peking University and other universities. With the project "Nucleic acid tracker: a portable, single base, non-amplification, CRISPR/Cas based nucleic acid testing platform", the team won a gold medal and achieved a breakthrough in the international genetic engineering machine competition.
Group photo of HainanU_China
The team developed a nucleic acid detection platform based on CRISPR/Cas13a&14a and Csm6 proteins, and added PNA to reduce miss rates. The platform was applied to portable, rapid, and accurate detection of marine microbial resistance. Compared with traditional microbiological detection methods based on ELISA, RT-PCR, and molecular diagnosis, this scheme is characterized by high efficiency, low cost, and strong specificity, reducing the requirements for large-scale testing equipment and professionals. The team demonstrated the feasibility of this design through experiments and theoretical analysis, utilizing the concatenation of multiple unrelated enzymes.
Page of iGEM Result
Experiment Design
It is learned that this competition was established by the Massachusetts Institute of Technology (MIT) in the United States in 2003 and has now developed into an international top competition in the field of synthetic biology. It is also an interdisciplinary competition involving interdisciplinary cooperation in fields such as mathematics, computer science, and statistics. The status and research achievements of the competition are receiving attention from academic journals such as Science and Nature every year, and have a wide international influence.
(Reporter Lü Yanping, Correspondent Wan Yi)
Team Members
Head of students |
School of Tropical Crops: Tang Rongkai; School of Life Sciences: Huang Shuo |
Student members and advisors |
School of Tropical Crops：Liang Moyan, Zhao Xuerui, Tan Tianyu School of Life Sciences: Hu Die, Zhou Yuhang, Wang Xiaoxia, Li Han, Yang Xiaoyu, Li Xiaoyang, Chen Manman, and Lan Qinglan School of Foreign Languages: Wang Shiyue School of Cyberspace Security: Chen Hongyu School of Chemical Engineering and Technology: Shi Huiru School of Computer Science and Technology: Wang Shibo School of Art and Design: Cheng Yijie, Cheng Siyu, Zhong Ye HNU-ASU Joint International Tourism College: Tao Xinshui School of Marine Sciences: Xiao Yunxiang School of Information Communication and Engineering: Shang Wenkai, Peng Shengsen State Key Laboratory of Marine Resources Utilization in the South China Sea: Li Anyi |
Main Instructor |
State Key Laboratory of Marine Resources Utilization in the South China Sea: Researcher Wan Yi |
Second Instructor State Key Laboratory of Marine Resources Utilization in the South China Sea: Postdoctor Wang Buhua School of Tropical Crops: Professor Chen Yinhua School of Life Sciences: Professor Zhou Hailong |
Consultant Teacher |
School of Tropical Crops: Lecturer Yan Ping School of Life Sciences: Professor Liao Chenghong School of Art and Design: Dr. Du Wei |
（Editor：Wang Yiqin)
