Key Findings-Hainan University

Professor Zhang Jiachao's Team Unravels the Mechanism of Tropical Probiotics in Alleviating the Side Effects of Lovastatin Drugs

Abstract:The existence of the gut microbiota produces an “individual drug reaction”. As members of the intestinal microbiota, probiotics, although they have prebiotic functions, may accelerate the degradation of drugs, thereby affecting drug efficacy. Lovastatin is one of the well-recognized lipid-lowering drugs. Its main action site is the liver. Therefore, if it is degraded in advance by gastrointestinal ...

Professor Li Jing's Team Discovers Temperature Manipulation Optimizes Plant Haploid Induction Efficiency

Abstract：Haploid production by outcrossing with inducers is one of the key technologies to revolutionize breeding. A promising approach for developing haploid inducers is by manipulating centromere-specific histone H3 (CENH3/CENPA). GFP-tailswap, a CENH3-based inducer, induces paternal haploids at around 30% and maternal haploids at around 5%. However, male sterility of GFP-tailswap makes high-demand ...

Functional Multi-Omics Reveals Carbon-Nitrogen Balance Regulatory Mechanisms in Phaeodactylum tricornutum by Xie Zhenyu's Research Group at Hainan University

Abstract：Background: Phaeodactylum tricornutum accumulates lipids while the growth also increases under high CO2, shedding light on its potential application in the reduction of CO2 emissions and at the same time acquiring biodiesel raw materials. However, the sensing and transducing of high C: N signals and the related response mechanism(s) remained unknown.Results: In this study, a multiple omics ...

Professor Liu Qian's Team from the School of Biomedical Engineering Makes Significant Progress in the Field of Biomedical Optoelectronic Detection

Abstract:High-resolution multi-modal magnetic resonance imaging (MRI) is crucial in clinical practice for accurate diagnosis and treatment. However, challenges such as budget constraints, potential contrast agent deposition, and image corruption often limit the acquisition of multiple sequences from a single patient. Therefore, the development of novel methods to reconstruct under-sampled images and ...

Professor Zhou Feifan's Team Makes New Progress in the Study of Immune Regulation Mechanisms in Addiction

Abstract:Chronic morphine exposure causes the development of addictive behaviors, accompanied by an increase in neuroinflammation in the central nervous system. While previous researches have shown that astrocytes contribute to brain diseases, the role of astrocyte in morphine addiction through induced neuroinflammation remain unexplored. Here we show that morphine-induced inflammation requires the ...

Undergraduate Students from the School of Biomedical Engineering Published High-Level Academic Paper as Lead Authors Abstract

Abstract:The prokaryote-derived gene defense system as a new generation of nucleic acid detection tool exhibits impressive performance in the field of molecular diagnosis. Prokaryotic Argonaute (Ago) is a CRISPR-associated protein that is guided by a short DNA (gDNA) and then efficiently cleaves gDNA-complementary nucleic acids and presents unique characteristics that are different from the CRISPR/...

Flexible Electronics Research Group in School of Biomedical Engineering: breakthrough on the fabrication and biomedical application of stretchable fibers (Science Advances)

Abstract:Stretchable polymeric fibers have enormous potential, but their production requires rigorous environmental controls and considerable resource consumption. It's also challenging for elastic polymers with high performance but poor spinnability, such as silicones like polydimethylsiloxane and Ecoflex. We present a hydrogel-assisted microfluidic spinning (HAMS) method to address these challenges ...

Team Led by Luo Qingming Reveals the Neural Circuit Mechanism Behind Short-Term Learning and Memory Impairment in Alzheimer’s Disease

AbstractShort-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in Alzheimer’s disease (AD) and AD mouse models. Extratelencephalic projection (ET) neurons in the PFC play a key role in short-term working memory, but the mechanism between ET neuronal dysfunction in the PFC and short-term memory impairment in AD is not well understood. Here, using fiber photometry and ...

Progress in the Research by Luo Qingming's Team Published in PNAS: Establishing a Method for Resolving the Patterns of Long-Range Projections of Specific Neuron Types at the Synaptic Level

AbstractThrough synaptic connections, long-range circuits transmit information among neurons and connect different brain regions to form functional motifs and execute specific functions. Tracing the synaptic distribution of specific neurons requires submicron-level resolution information. However, it is a great challenge to map the synaptic terminals completely because these fine structures span multiple ...

Professor Xilong Wu of the School of Biomedical Engineering Achieves Significant Research Progress in Anti-Biofouling Field

Abstract:The complexity of nuclear industry effluents necessitates novel treatment capable of facilitating water recycling and byproduct recovery. Many membrane-based technologies have become increasingly important for sewage water disposal because of their simple operation and scale-up for industrial applications. However, the membrane biofouling due to microbial attachment has become a serious issue,...