张立定

张立定，海南大学生物医学工程学院博士后。2023年6月博士毕业于华中科技大学武汉光电国家研究中心，在骆海明教授的指导下从事阿尔兹海默病诊断与靶向治疗方面的研究，获生物医学光子学博士学位。2023年7月进入海南大学生物学博士后流动站工作。

主要研究方向：

1） 阿尔兹海默病早期诊断

2） 阿尔兹海默病脑内相关病理蛋白的标记与成像

学术论文：

1.Liding Zhang#,Ying Su#, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo.Ultrasensitive and point-of-care detection of plasma biomarker in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assay. Nano Research. 2023; 16(5):7459-7469. (IF=9.9)

2.Liding Zhang, Kai Cao, Ying Su, Shun Hu, Xiaohan Liang, Qingming Luo, Haiming Luo. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensors and Bioelectronics. 2022; 222:114935. (IF=12.6)

3.Liding Zhang#, Xuewei Du#, Ying Su#, Shiqi Niu, Yanqing Li, Xiaohan Liang, Haiming Luo.Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021; 19(1):366. (IF=10.2)

4. Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo.Dynamic changes in the levels of amyloid-β₄₂species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer’s disease. Frontiers In Molecular Neuroscience. 2021; 14:723317. (IF=4.8)

5.Wensheng Qu#,Liding Zhang#, Xiaohan Liang, Zhiyuan Yu, Hao Huang, Jing Zhao, Yinping Guo, Xirui Zhou, Shabei Xu, Haiming Luo, Xiang Luo. Elevated Plasma Oligomeric Amyloid β-42 is Associated with Cognitive Impairments in Cerebral Small Vessel Disease. Biosensors. 2023,13(1):110. (IF=5.4)

6. Liding Zhang#, Xuewei Du#, Zhixin Chen, Congjie Chen, Nanxin Gong, Yihao Song, Yuzhu Song, Qinqin Han, Xueshan Xia, Haiming Luo, Jinyang Zhang. Instrument-Free and Visual Detection of Salmonella Based on the Magnetic Nanoparticles and Antibody-Probe Immunosensor. International Journal of Molecular Sciences. 2019,20 (18):4645. (IF=5.6)

7. Liding Zhang#, Qiujiang Wei#, Qinqin Han, Qiang Chen, Wenlin Tai, Jinyang Zhang, Yuzhu Song, Xueshan Xia. Detection of Shigella in Milk and Clinical Samples by Magnetic Immunocaptured-Loop-Mediated Isothermal Amplification Assay. Frontiers in Microbiology. 2018,9:94. (IF=5.2)

8. Liding Zhang#, Xuewei Du#, Congjie Chen, Zhixin Chen, Li Zhang, Qinqin Han, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development and Characterization of Double-antibody Sandwich ELISA for Detection of Zika Virus Infection. Viruses. 2018,10(11): 634. (IF=4.7)

9. Liding Zhang, Yaoqiang Shi, Congjie Chen, Qinqin Han, Qiang Chen, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Rapid, Visual Detection of Klebsiella pneumoniae Using Magnetic Nanoparticles and a Horseradish Peroxidase-Probe Based Immunosensor. Journal of Biomedical Nanotechnology. 2019,15:1061-1071. (IF=2.9)

10. Liding Zhang,Xiaohan Liang, Zhihong Zhang, and Haiming Luo. Cerebrospinal fluid and blood biomarkers in the diagnostic assays of Alzheimer's disease. Journal of Innovative Optical Health Sciences. 2022; 15(1)223001. (IF=2.5)

11. Liding Zhang,Xuewei Du, Qiujiang Wei, Qinqin Han, Qiang Chen, Mi Zhang, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development and Application of an Immunocapture PCR Diagnostic Assay Based on the Monoclonal Antibody for the Detection of Shigella. Iranian Journal of Biotechnology. 2020,18(1): e2244. (IF=1.3)

12. Liding Zhang#, Xuewei Du#, Qian Chen, Qinqin Han, Qian Chen, Mi Zhang, Xueshan Xia, Yuzhu Song, Jinyang Zhang. Development of a rapid, one-step-visual method to detect Salmonella based on immunocapture-Loop Mediated Isothermal Amplification. Iranian Journal of Veterinary Research. 2020,21(1): 20-25. (IF=1.2)

专利：

1.张金阳，张立定。肺炎克雷伯杆菌的IC-PCR检测引物组及其应用。专利号：ZL201811342422.1

2.张金阳，张立定。用于检测肺炎克雷伯杆菌的特异性抗体组及应用。专利号：ZL201810261060.7

3.张金阳，张立定。一种单克隆抗体及其应用。专利号：ZL201811342423.6

4.骆海明，张立定。分泌人淀粉样蛋白-β单克隆抗体的杂交瘤细胞株及其应用。专利号：ZL202011227808.5。

5.骆海明，张立定。用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒。专利号：ZL202011227418.8

6.骆海明，骆清铭，张立定。一种用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备。专利号：ZL2021110067679.6

7.骆海明，张立定。二种分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株。专利号：ZL202110067436.2

8.骆海明，张立定。一种用于阿尔茨海默病诊疗一体化的多功能的纳米粒子。专利号：ZL202110518125.3

科研项目：

国家自然科学基金面上项目（81971025）：活化小胶质细胞的特异性标记及在阿尔兹海默症进展期间通过动态分子成像区分其表型的研究，2020.01-2023.12，参与。

获奖与荣誉称号：

第十五届生物学和医学光子学与成像国际会议PIBM“最佳学生论文奖”

2022年获得华中科技大学武汉国家研究中心国光学子一等奖学金

2022年获得华中科技大学华中科技大学三好研究生

2023年获得华中科技大学博士优秀学业奖学金