郭哲杉(博士)。海南省“南海新星”产业创新创业人才(首批)、海南省高层次人才。上海理工大学学士(2012);浙江大学博士(2019)。美国明尼苏达大学神经调控中心博士后(2019~2022);应脉医疗科技(上海)有限公司神经调控部高级科学家(2022)。2022年12月入职海南大学生物医学工程学院,加入殷明教授脑机芯片神经工程团队。
研究方向:
基于脑机接口的在体电生理信息及神经调控,结合影像学、计算机建模等手段,研究神经调控治疗帕金森病、阿尔茨海默症、癫痫、抑郁症等神经系统疾病的神经机制,并开发新型神经调控方法。研究领域涉及神经调控、脑机接口、脑电信号分析与处理等。
学术论文:
1.Wang Y, Yin M*, andGuo Z*. Circuit-specific gene therapy is knocking on the door of Parkinson’s disease[J]. Zoological Research, 2023, 44(6): 1152.
2. Guo Z, Feng Z*, Wang Y & Wei X. Simulation study of intermittent axonal block and desynchronization effect induced by high-frequency stimulation of electrical pulses[J]. Frontiers in Neuroscience, 2018, 12:858.
3. Guo Z, Feng Z*, Yu Y, et al. Sinusoidal stimulation trains suppress epileptiform spikes induced by 4-AP in the rat hippocampal CA1 region in-vivo[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5817.
4.Zheng L, Feng Z*,Guo Z, Huang L. Simulation Study of Intermittent Responses of Neuronal Populations to Axonal High-Frequency Stimulation[C]. Conf Proc IEEE Eng Med Biol Soc, 2019: 3001-3004.
5.Feng Z*,Guo Z, Wang Z. Advances in Understanding The Mechanisms of Deep Brain Stimulation[J]. Progress in Biochemistry and Biophysics, 2018, 45(12): 1197-1203.
6.Cai Z, Feng Z*,Guo Z, Zhou W, Wang Z & Wei X. Novel stimulation paradigms with temporally-varying parameters to reduce synchronous activity at the onset of high frequency stimulation in rat hippocampus[J]. Frontiers in Neuroscience, 2017, 11:563.
7.Feng Z*, Wang Z,Guo Z, Zhou W, Cai Z & Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction[J]. Brain Research, 2017, 1661:67.
8.Yu Y, Feng Z*, Cao J,Guo Z, Wang Z, Hu N & Wei X. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region[J]. Journal of Integrative Neuroscience, 2016, 15(01):1-17.
9.Wang Z, Feng Z*, Yu Y, Zhu Y &Guo Z. Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5813.
10.Feng Z*, Yu Y,Guo Z, Cao J & Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus[J]. Brain stimulation, 2014, 7(5): 680-689.
主持和参与的部分科研项目:
1. 海南省科技人才创新项目:基于脑机接口的猕猴帕金森病运动徐缓症状神经机制研究,KJRC2023L01,2024.01-2026.12,50万元,主持
2. 海南省“南海新星”产业创新创业人才平台项目:脑机交互新型手部外骨骼康复机器人,2023-2026,30万元,共同主持
3. 美国国立卫生研究院项目:“Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey”,4R37NS077657-10,2012-2025,67万美元, 参与
4. 美国国立卫生研究院项目:“Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS”( 5R01NS037019-23),1999-2023,220万美元, 参与
授权专利:
多功能神经电刺激系统控制软件V1.0. 2015SR110707, 2015. (第二发明人)
招生需求:
招收生物医学工程、控制、计算机、自动化、人工智能、神经科学、医学、生物及相关专业的研究生。
联系方式:guozheshan@hainanu.edu.cn