陈茂华

陈茂华（博士），海南大学生物医学工程学院，副教授。2013年本科毕业于西南交通大学材料科学与工程学院生物医学工程专业，获工学学士学位；2019年9月博士毕业于西南交通大学材料科学与工程学院材料科学与工程专业，获工学博士学位；2019.10-2021.11于深圳大学从事科研工作；2022年3月加入海南大学生物医学工程学院。

主要研究方向：
1）生物医用高分子的设计与合成
2）智能响应药物控释体系的构建
3）非抗生素纳米抗菌材料的构建

代表性学术论文：
1、M.H. Chen†; J.J. Zhou†; P. Ran; F.M. Lei; J. Meng; J.W. Wei; X.H. Li*; Photoactivated Release of Nitric Oxide and Antimicrobial Peptide Derivatives for Synergistic Therapy of Bacterial Skin Abscesses. Advanced Healthcare Materials 2022, 2200199.

2、M.H. Chen†; B. Qiu†; Z.L. Zhang; S. Xie; Y. Liu; T, Xia*; X.H. Li*; Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria, Chemical Engineering Journal, 2021.424, 130330. IF=13.273

3、M.H. Chen†; J. He†; S.Z. Xie; T. Wang; P. Ran; Z.L. Zhang; X.H. Li*; Intracellular bacteria destruction via traceable enzymes-responsive release and deferoxamine-mediated ingestion of antibiotics, Journal of Controlled Release, 2020.322, 326-336. IF=9.776

4、Z.H. Ding†;M.H. Chen†; X.Y. Tao; Y. Liu; J. He; T Wang*; X.H. Li*; Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues, ACS Biomaterials-Science & Engineering. 2020, 7, 727-738. IF=4.749

5、M.H. Chen; J.J. Wei; S.Z. Xie; X.Y. Tao; Z.L. Zhang; P. Ran; X.H. Li*; Bacterial biofilm destruction by size/surface charge-adaptive micelles, Nanoscale, 2018, 11, 1401. IF=7.79

6、M.H. Chen; S.Z. Xie; J.J. Wei; X.J. Song; Z.H. Ding; X.H. Li*; Antibacterial Micelles with Vancomycin-Mediated Targeting and pH/Lipase-Triggered Release of Antibiotics, ACS Applied Materials & Interfaces, 2018. 10, 36814−36823. IF=9.229

7、X.M. Luo†;M.H. Chen†; Z.J. Chen; S.Z. Xie; N. He; T. Wang; X.H. Li*; An implantable depot capable of in situ generation of micelles to achieve controlled and targeted tumor chemotherapy, Acta Biomaterialia, 2018, 67, 122-133. IF=8.947

8、M.H. Chen; Y. Zhang; Z.J. Chen; S.Z. Xie; X.M. Luo; X.H. Li*; Synergistic antitumor efficacy of redox and pH dually responsive micelleplexes for co-delivery of camptothecin and genes, Acta Biomaterialia, 2017, 49, 444-455. IF=8.947

9、Y. Zhang†;M.H. Chen†; X.M. Luo; H. Zhang; C.Y. Liu; H.Y. Li; X.H. Li*; Tuning multiple arms for camptothecin and folate conjugations on star-shaped copolymers to enhance glutathione-mediated intracellular drug delivery. Polymer Chemistry. 2015, 6, 2192 IF=5.582.

主持科研项目：

1、国家自然科学基金项目（地区）（32360238），2024.01-2027.12

2、海南省自然科学基金高层次人才项目（524RC479），2024.03-2027.02

3、海南大学高层次人才科研启动基金（RZ2300002644），2022.04-2027.04

招收生物医学工程、化学、材料、生物等相关专业的2-3名硕博研究生

联系方式：maohuachen@hainanu.edu.cn